Diamondbacks vs. Cardinals: Game 2 prediction, odds, injuries, and picks

The Arizona Diamondbacks and St. Louis Cardinals are set to continue their three-game series on Saturday at Busch Stadium. Arizona is looking to bounce back after dropping the series opener to St. Louis.

The Diamondbacks are now sitting at 26-25 on the season, while the Cardinals have been slightly better at 28-23 on the season. Both teams look like playoff contenders early in the season, and this should be a great weekend of baseball.

Here is a look at the odds for this game and some predictions to make.

Diamondbacks vs. Cardinals prediction

Nolan Arenado is having a big season: Imagn

The Arizona Diamondbacks have been a tough team to figure out this season as they have been incredibly streaky. Arizona has belted 72 home runs this season and Corbin Carroll leads the way with 15 home runs.

Merrill Kelly will be on the mound for the Diamondbacks in this matchup and he has gone 5-2 with a 3.26 ERA so far this season. Arizona needs a great start from Kelly to give the offense a chance to deliver.

Matthew Liberatore will take the ball for the St. Louis Cardinals and he keeps getting better with each start. Liberatore has gone 3-3 with a 2.92 ERA so far this season, but he has to keep the ball in the park.

Lars Nootbar leads the Cardinals with seven home runs this season, but they don't have a ton of power. Look for the Diamondbacks to take control of this game with the offense.

Diamondbacks vs. Cardinals odds

Money Line: Arizona Diamondbacks EVEN, St. Louis Cardinals (-120)

Run Spread: Diamondbacks +1.5 (+165), Cardinals -1.5 (-200)

Total Runs: Over 7.5 (-120), Under 7.5 (EVEN)

Diamondbacks vs. Cardinals injuries

Arizona Diamondbacks injury report

Eduardo Rodriguez (LHP): 15-Day IL (Left shoulder inflammation)

A.J. Puk (LHP): 60-Day IL (Left shoulder inflammation)

Jordan Montgomery (LHP): Entire season (Torn UCL)

St. Louis Cardinals injury report

Willson Contreras (1B): TBD (Back spasms)

Zack Thompson (LHP): 60-Day IL (Left lat strain)

Diamondbacks vs. Cardinals picks

St. Louis might have won the series opener, but the focus should be on the Diamondbacks in this game. Arizona is going to even up the series and should be the focus when making picks.

Money Line: Arizona Diamondbacks EVEN

Run Spread: Diamondbacks +1.5 (+165)

Total Runs: Over 7.5 (-120)

About the author

Ryan Burks is a baseball journalist at Sportskeeda with over 7 years of experience in the field, writing for publications such as Knup Sports. Ryan graduated from Elmhurst College in 2009 with a degree in Communications.

Ryan is a huge Chicago Cubs fan and enjoys their storied history and traditions. His favorite sporting moment was when the Cubs won the 2016 World Series, breaking a championship drought that dated back to 1908.

His favorite player was Ken Griffey Jr., as Ryan grew up during his prime and he was the coolest player in league history. Greg Maddux also deserves a mention, as he was truly amazing on the mound.

When not working or watching sports, Ryan coaches basketball and baseball, loves fishing, and spends time with his family.

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Edited by Rajdeep Barman

Diamondbacks vs. Cardinals: Game 2 prediction, odds, injuries, and picks - May 24, 2025