Dodgers vs Cardinals: Game 1 prediction, odds, injuries, and picks - June 6, 2025

St. Louis Cardinals v Los Angeles Dodgers - Source: Getty
St. Louis Cardinals v Los Angeles Dodgers - Source: Getty

The defending champion LA Dodgers are heading to the Gateway of the West for a three-game series against old foes in the St. Louis Cardinals. A rivalry that precedes the establishment of MLB itself, the Cards currently have the upper hand against their combatants in the all-time matchup records.

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However, Los Angeles has seen more success in the 2020s as the team dominated the Cardinals in the series scoreline at 18-10. Game 1 should see an exciting matchup as the Cards have elected to deploy three-time All-Star Sonny Gray to face off against the unproven Justin Wrobleski on the bump.

Dodgers vs. Cardinals recent form and records

After a close battle in their most recent series against the Mets, the World Series champions managed to eke out a series victory after two come-from-behind wins. They still maintain the top standing in the NL West at 38-25 and hold a 15-14 record on the road.

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The Cardinals, meanwhile, have lost consecutive series at the hands of the Rangers and the I-70 rivalry matchup with the Royals. They've posted a 34-28 record that is second-best in the NL Central, are just half a game behind in the wild card spots, and possess an impressive 20-10 card at home so far.

Dodgers vs. Cardinals odds

Money Line: LAD (+108), STL (-118)

Run Spread: LAD -1.5 (+162), STL +1.5 (-205)

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Total Runs: O 8.5 (-106), U 8.5 (-113)

Dodgers vs. Cardinals injuries

LAD injury report

  • Roki Sasaki (SP): 15-day IL (shoulder)
  • Tyler Glasnow (SP): 60-day IL (shoulder)
  • Blake Snell (SP): 60-day IL (shoulder)
  • Emmet Sheehan (SP): 60-day IL (elbow)
  • Gavin Stone (SP): 60-day IL (shoulder)
  • River Ryan (SP): 60-day IL (elbow)
  • Kirby Yates (RP): 15-day IL (hamstring)
  • Michael Kopech (RP): 60-day IL (shoulder)
  • Evan Phillips (RP): 60-day IL (elbow)
  • Brusdar Graterol (RP): 60-day IL (shoulder)
  • Blake Treinen (RP): 60-day IL (forearm)
  • Luis Garcia (RP): 15-day IL (adductor)
  • Michael Grove (RP): 60-day IL (shoulder)
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STL injury report

  • Matthew Liberatore (SP): Day-to-day (fatigue)
  • Jordan Walker (RF): 10-day IL (wrist)
  • Zack Thompson (RP): 60-day IL (lat)

Dodgers vs. Cardinals projected lineup

Los Angeles Dodgers projected lineup

  • Shohei Ohtani (DH)
  • Mookie Betts (SS)
  • Freddie Freeman (1B)
  • Will Smith (C)
  • Teoscar Hernandez (RF)
  • Max Muncy (3B)
  • Andy Pages (CF)
  • Michael Conforto (LF)
  • Tommy Edman (2B)
  • Justin Wrobleski (SP, 1-1 | 8.00 ERA | 8 K)

STL projected lineup

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  • Lars Nootbaar (LF)
  • Masyn Winn (SS)
  • Brendan Donovan (2B)
  • Willson Contreras (1B)
  • Ivan Herrera (DH)
  • Nolan Arenado (3B)
  • Alex Burleson (RF)
  • Pedro Pages (C)
  • Victor Scott (CF)
  • Sonny Gray (SP, 6-1 | 3.65 ERA | 76 K)

Dodgers vs. Cardinals picks and game prediction

The Cardinals are favored in the contest, given that Sonny Gray would start against a fill-in starter for Los Angeles. However, the champions have proven time and again that they can come back from even the biggest of leads against the titans of the MLB, such as the Yankees and Mets.

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Game 1 should provide a blueprint on how St. Louis handles matchups against the league's best teams.

Run Line: STL +1.5 (-205)

Total Runs: U 8.5 (-113)

Prediction: LAD wins, 4-3

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Edited by Daniel Santiago
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