Padres vs. Brewers: Game 1 prediction, odds, injuries and picks

The Milwaukee Brewers host the San Diego Padres for a three-game series over the weekend. Both National League teams meet for the first time this season, looking to do better than their shortened playoff performances last year.

The Brewers (34-29) head into the series having won nine of their last 10 games. They have been steadily rising in the NL Central standings and are 5.5 games behind the Chicago Cubs for first place. Milwaukee has won three of the last four division titles.

The Padres (35-26) were able to take the first two games of their four-game encounter against division rivals the San Francisco Giants. However, they lost the last two to keep the distance between themselves them and the LA Dodgers at the top of the NL West.

Padres vs. Brewers Game 1: Betting odds & weather

Date: Friday, June 6, 2025 at 8:10 p.m. ET

Money line: Brewers -144

Over/Under: Under 8.5 runs

Weather: Not applicable, in domed stadium

Padres vs. Brewers Game 1: Injuries & lineups

Injuries

Padres

Luis Arraez: day-to-day (knee)
Xander Bogaerts: day-to-day (shoulder)
Michael King: 15-day IL (shoulder)
Jason Heyward: 10-day IL (oblique)
Mason McCoy: 10-day IL (finger)
Bryan Hoeing: 60-day IL (shoulder)
Logan Gillaspie: 15-day IL (oblique )
Jhony Brito: 60-day IL (forearm)
Yu Darvish: 15-day IL (elbow)
Joe Musgrove: 60-day IL (elbow)

Brewers

Connor Thomas: 60-day IL (elbow)
Blake Perkins: 60-day IL (shin)
Garrett Mitchell: 10-day IL (oblique)
Nestor Cortes: 60-day IL (elbow)
Brandon Woodruff: 15-day IL (shoulder)
Robert Gasser: 60-day IL (elbow)

Expected lineups

Padres

RF F. Tatis (R)
1B Luis Arraez (L)
3B M. Machado (R)
CF J. Merrill (L)
DH Gavin Sheets (L)
SS X. Bogaerts (R)
2B J. Cronenworth (L)
LF Tyler Wade (L)
C Elias Diaz (R)

Brewers

2B Brice Turang (L)
CF J. Chourio (R)
C W. Contreras (R)
DH C. Yelich (L)
1B Rhys Hoskins (R)
LF I. Collins (S)
RF Sal Frelick (L)
3B Caleb Durbin (R)
SS Joey Ortiz (R)

Padres vs. Brewers Game 1: Prediction and picks

The Padres' Randy Vasquez (3-4, 3.99 ERA, 1.47 WHIP, 35 strikeouts) will go up against the Brewers' Chad Patrick (3-4, 2.97 ERA, 1.21 WHIP, 57 strikeouts). Patrick has the edge and is entering the game with form, having earned just three runs in his last three starts. Meanwhile, Vasquez has earned nine over that stretch.

Milwaukee's strong form in the last 10 has been mostly due to an offense hitting at .268 collectively. Christian Yelich has 11 RBIs over that span, going 17-for-42, while Sal Frelick leads the team with a .291 average.

San Diego needs to improve from its .226 average over the last 10. Jackson Merrill has been the best hitter for the team, driving in five RBIs.

Prediction: Brewers 5, Padres 4

Picks: Under 8.5 runs

About the author

Nikhil Parshy is a baseball and ice hockey journalist at Sportskeeda, and after starting out as a cricket reporter, he has been an analyst with SK since November 2022. His interest in the sports were piqued a few years back after watching highlights on YouTube and he has followed the game ever since.

The Chicago Cubs breaking the 108-year curse in 2016 to lift the World Series remains Nikhil's favorite baseball moment. Two-way phenom Shohei Ohtani has been his favorite player ever since he started following the game, while the LA Dodgers are his favorite team.

As a writer, Nikhil maintains a strong attention to detail and rigorously cross-checks information. He seeks to strike a balance in his writing such that the regular reader gains an insight into player profiles, while also keeping in mind that the non-regular reader is not put off by jargon and shallow analysis.

Nikhil is an avid public speaker, and when not writing about baseball, he regularly participates in debates and quizzes.

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Edited by Victor Ramon Galvez

Padres vs. Brewers: Game 1 prediction, odds, injuries and picks - June 6, 2025

Padres vs. Brewers Game 1: Betting odds & weather

Padres vs. Brewers Game 1: Injuries & lineups

Injuries

Padres

Brewers

Expected lineups

Padres

Brewers

Padres vs. Brewers Game 1: Prediction and picks