Padres vs Giants: Game 4 prediction, odds, injuries, and picks - June 5, 2025

San Diego Padres v San Francisco Giants - Source: Getty
San Diego Padres v San Francisco Giants - Source: Getty

The Giants will be hosting the Padres for the final game of the four-game set between the two squads as they look salvage the series and end it with a tie. After losing the first two contests in close fashion, San Francisco was able to clutch the game away from San Diego in Game 3 with a score of 6-5.

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San Diego led the hosts 5-0 up until the fifth inning. However, seemingly tired of losing close games against their divisional foes, San Francisco woke up through Patrick Bailey's RBI-double. This was followed up by Matt Chapman's solo home run, Heliot Ramos' two-run double, and Jung Hoo Lee's sacrifice fly that drove in Tyler Fitzgerald.

By the end of the seventh frame, the hosts have taken the lead at 6-5. Reliever Randy Rodriguez recorded his first career save in his 26th appearance for San Francisco this season.

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Padres vs. Giants recent form and records

With the win, the Giants ended their losing skid against the Padres and improved their record to 34-28. They now possess an 18-11 record at home and a +41 run differential.

The Friars, on the other hand, have lst just their third game of the past 10 contests with a 35-25 record. The squad is currently two games ahead of San Francisco for the second spot in the stacked NL West and are just a game behind the reigning champion Dodgers.

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Padres vs. Giants odds

Money Line: SD (+104), SF (-112)

Run Spread: SD -1.5 (+169), SF +1.5 (-212)

Total Runs: O 7.5 (+103), U 7.5 (-123)

Padres vs. Giants injuries

SD injury report

  • Ethan Salas (C): Day-to-day (back)
  • Logan Gillespie (RP): 15-day IL (oblique)
  • Jhony Brito (RP): 60-day IL (elbow, flexor tendon)
  • Yu Darvish (SP): 15-day IL (elbow)
  • Bryan Hoeing (RP): 60-day IL (shoulder)
  • Michael King (SP): 15-day IL (shoulder)
  • Jason Heyward (LF): 10-day IL (oblique)
  • Joe Musgrove (SP): 60-day IL (elbow)
  • Mason McCoy (2B): 10-day IL (finger)
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SF injury report

  • Kyle Harrison (RP): Day-to-day (elbow)
  • Justin Verlander (SP): 15-day IL (pectoral)
  • Tom Murphy (C): 60-day IL (back)
  • Jordan Hicks (SP): 15-day IL (toe)

Padres vs. Giants projected lineup

SD projected lineup

  • Fernando Tatis Jr. (RF)
  • Luis Arraez (1B)
  • Manny Machado (3B)
  • Jackson Merrill (CF)
  • Xander Bogaerts (SS)
  • Gavin Sheets (LF)
  • Luis Campusano (DH)
  • Jake Cronenworth (2B)
  • Martin Maldonado (C)
  • Dylan Cease (SP, 1-4 | 4.66 ERA | 78 K)
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SF projected lineup

  • Heliot Ramos (LF)
  • Jung Hoo Lee (CF)
  • Wilmer Flores (DH)
  • Matt Chapman (3B)
  • Willy Adames (SS)
  • Mike Yastrzemski (RF)
  • Dominic Smith (1B)
  • Patrick Bailey (C)
  • Tyler Fitzgerald (2B)
  • Robbie Ray (SP, 7-1 | 2.43 ERA | 78 K)

Padres vs. Giants picks and game prediction

San Francisco is slightly favored in the closing game of the series. A vital part of this is starter Robbie Ray's solid season on the mound so far. The former Cy Young Awardee will carry his 7-1 record and 2.43 ERA across 12 starts against a struggling Dylan Cease who will take the bump for San Diego. Cease has just won one of his 12 appearances for the Friars this year and has produced a 4.66 ERA.

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Run Line: SF +1.5 (-212)

Total Runs: O 7.5 (+109)

Prediction: SF wins, 5-3

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Edited by Daniel Santiago
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