Red Sox vs. Orioles: Game 4 prediction, odds, injuries, and picks

The Boston Red Sox seek retribution for their surprising 2-1 loss at the hands of the Baltimore Orioles in Game 3 of their four-game series. After overwhelming the visitors in Game 1 and winning the first of the double-header yesterday, Boston were narrowly edged out by Baltimore in a game wherein the runs were scored in the dying embers of the contest.

Ryan O'Hearn's RBI-single and Dylan Carlson's RBI-double were enough to keep Boston at bay with the latter only being able to score through Abraham Toro's solo shot in the ninth.

Red Sox vs. Orioles recent form and records

Boston continues to be a middle-of-the-pack team both in terms of their statistics and in terms of their win-loss record. They currently possess a 27-27 record that is good for the second-best in the AL East.

The Orioles, meanwhile, have left much to be desired this year. Outside of the struggling Rockies, the team has posted the second-worst run differential at -99. With a 17-34 record, they are at the basement of the AL East and if not for the White Sox, they would be at the very bottom of the American League standings as well.

Players to watch

Starting pitchers

BOS: Walker Buehler (4-1, 4.00 ERA, 33 K), BAL: Dean Kremer (3-5, 5.50 ERA, 40 K)

Boston Red Sox

Two-time World Series champion Walker Buehler has had a respectable start for his new club. Buehler has posted a 4-1 record with a 4.00 ERA and 33 strikeouts across seven games.

Unlike his previous years, Buehler has strayed away from his reliance of his fastball and has increased his usage of sweepers and changeups. The diversity of his pitches has placed him within the 94th-percentile in average exit velocity and 93rd-percentile in hard-hit percentage, meaning that he rarely lets hitters go yard with his pitches.

Must-Watch Hitters

Baltimore Orioles

Although the pitching staff has been disastrous, the Orioles' offense has been the streak of light in their dark season. Once such case is Ryan O'Hearn who has tallied seven home runs and 17 RBI. He's also batting at a decent .315/.405/.500 with an OPS of .905.

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Red Sox vs. Orioles baseball betting odds

Sunday, 5/25	Money Line	Run Line	Total Runs
BOS	-135	-1.5, +144	O 9.5, -105
BAL	+122	+1.5, -177	U 9.5, -115

Red Sox vs. Orioles expert picks and game prediction

The Red Sox are quite favored in the series-closer at home. Even though they've had their own share of struggles this year, it isn't enough to simply be overwhelmed by a flailing Orioles team.

Run Line: -1.5, +144

Total Runs: O 9.5, -105

Prediction: BOS wins, 8-3

About the author

Daniel Santiago is a journalist who has been reporting on baseball at Sportskeeda since 2022. He was drawn towards the sport after the underlying statistics and the analysis surrounding it grabbed his attention.

Daniel particularly enjoys furnishing reports about historic events in baseball and analyzing the game through a statistic-based outlook, based on Fangraphs and Baseball-Reference. This is in line with how he enjoyed watching baseball as a pastime. As a writer, he is very particular about cross-checking from reputable sources and doing his due diligence.

He became a lifelong Hideki Matsui fan after his exploits in the 2009 World Series for the New York Yankees. Among the current generation, Daniel's favorites include Shohei Ohtani and Jung Hoo Lee. Daniel is a huge follower of Asian baseball and both Ohtani and Lee have been in the top echelon of their respective leagues during their time with the NPB and KBO.

His favorite moment as a baseball fan was the final at-bat of the 2023 World Baseball Classic between Shohei Ohtani and Mike Trout. He believes there aren't many words to fittingly describe the intensity of the moment.

As an avid sports fan, Daniel watches other sports and Esports when not writing about baseball.

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Edited by Daniel Santiago

Red Sox vs. Orioles: Game 4 prediction, odds, injuries, and picks - May 25, 2025