There are so many ways to make predictions on the top MLB pitchers for games, but focusing on the strikeouts should be at the top of your list. Over/under odds are set for all pitcher's strikeouts numbers, and those are the predictions that you will want to make.
Some aces will be taking the mound, but you can find plenty of other top MLB pitchers to focus on when making prop bets. Here is a look at five of the over/under wagers that you are going to want to make.

Top MLB Pitchers Strikeouts Prop bets for June 15, 2025
Max Fried: Under 6.5 (-140)
Max Fried has been one of the top MLB pitchers so far during the 2025 season for the New York Yankees, but he has a tough matchup with the Boston Red Sox. Look for Fried to have another great start, but taking the under 6.5 strikeouts is the right pick.
Zack Wheeler: Over 6.5 (+105)

Zack Wheeler is seemingly dominant every time that he takes the mound, and he can overwhelm any lineup when he is throwing the ball well. Wheeler is facing a Toronto Blue Jays team that strikes out a ton, and taking the over is the way to go.
Nick Pivetta Over 4.5 (-150)

Nick Pivetta is 6-2 with a 3.48 ERA this season for the San Diego Padres, and he is set to start against the Arizona Diamondbacks. Pivetta will have a tough matchup in this game, but taking the over 4.5 strikeouts will prove to be a great option.
Safest pick of the day: Colin Rea Over 4.5 (-115)

The safest pick of the day to make is taking Colin Rea of the Chicago Cubs to strikeout at least five batters. Rea should have little trouble with the Pittsburgh Pirates as he delivers a big win for the Cubs.
Bold Prediction: Miles Mikolas Over 3.5 (+115)

You should always be looking to make a bold prediction when focusing on prop betting options, and Miles Mikolas is the player to watch on Sunday. Mikolas is not a big strikeout pitcher, but he will get to at least four strikeouts against the Milwaukee Brewers.