Yankees vs Red Sox: Game 1 prediction, odds, injuries and picks

On Friday, the New York Yankees will face the Boston Red Sox for the first time this season in the Bronx. The two teams will play a three-game series over the weekend, which is part of their 13-game slate scheduled this season.

The Yankees head into the series having won eight of the last nine series, dating back to their two wins against the San Diego Padres on May 7 and 8. They remain in sole possession of the AL East lead with a 38-23 record.

These three games are crucial for Boston to remain in the playoff hunt. The Red Sox have a 30-34 record and are 9.5 games behind New York. They suffered two losses against the Los Angeles Angels in their recent fixture.

Yankees vs. Red Sox Game 1: Betting Odds & Weather

Date: Friday, June 6, 2025, at 7:05 p.m. ET

Money Line: Yankees -176

Over/Under: Over nine runs

Weather: Partly cloudy, 82 degree F, 34% chance of precipitation, nine mph wind R-L

Yankees vs. Red Sox Game 1: Injuries & Lineups

Injuries

Yankees

Luke Weaver: 15-Day IL (hamstring)
Oswaldo Cabrera: 10-Day IL (ankle)
Giancarlo Stanton: 60-Day IL (elbow)
Marcus Stroman: 15-Day IL (knee)
JT Brubaker: 60-Day IL (ribs)
Jake Cousins: 60-Day IL (elbow)
Gerrit Cole: 60-Day IL (elbow)
Luis Gil: 60-Day IL (back)

Red Sox

Nick Burdi: 15-Day IL (knee)
Justin Slaten: 15-Day IL (shoulder)
Liam Hendriks: 15-Day IL (hip)
Alex Bregman: 10-Day IL (quadricep)
Triston Casas: 60-Day IL (knee)
Masataka Yoshida: 60-Day IL (shoulder)
Kutter Crawford: 60-Day IL (knee)
Tanner Houck: 15-Day IL (flexor)
Chris Murphy: 60-Day IL (elbow)
Patrick Sandoval: 60-Day IL (elbow)

Expected Lineups

Yankees

CF T. Grisham [L]
RF Aaron Judge [R]
LF C. Bellinger [L]
1B P. Goldschmidt [R]
DH J. Dominguez [S]
3B J. Chisholm [L]
SS A. Volpe [R]
C Austin Wells [L]
2B DJ LeMahieu [R]

Red Sox

LF Jarren Duran [L]
DH R. Devers [L]
RF Wilyer Abreu [L]
C C. Narvaez [R]
3B M. Mayer [L]
1B Abraham Toro [S]
SS Trevor Story [R]
2B K. Campbell [R]
CF C. Rafaela [R]

Yankees vs. Red Sox Game 1: Prediction and Picks

Red Sox starter Walker Buehler (4-3, 4.44 ERA, 1.31 WHIP, 42 strikeouts) and Yankees starter Will Warren (3-3, 5.19 ERA, 1.42 WHIP, 69 strikeouts) have had slightly decent starts to their season.

Although they would have wished for better returns, Buehler earned five runs against the Braves in his last appearance, while Warren earned seven against the Dodgers last week.

Aaron Judge and Paul Goldschmidt continue to lead the Yankees offence in different metrics. But they have found some help from Cody Bellinger, who has hit .313 with three RBIs and two extra-base hits in the last five games.

For the Red Sox, Rafael Devers has 54 RBIs this season, second in the league. Jarren Duran has 27 extra-base hits with a .274 average, while Wilyer Abreu leads the team with 13 homers.

Prediction: Yankees 6, Red Sox 4

Picks: Yankees -176, Over 9 runs

About the author

Nikhil Parshy is a baseball and ice hockey journalist at Sportskeeda, and after starting out as a cricket reporter, he has been an analyst with SK since November 2022. His interest in the sports were piqued a few years back after watching highlights on YouTube and he has followed the game ever since.

The Chicago Cubs breaking the 108-year curse in 2016 to lift the World Series remains Nikhil's favorite baseball moment. Two-way phenom Shohei Ohtani has been his favorite player ever since he started following the game, while the LA Dodgers are his favorite team.

As a writer, Nikhil maintains a strong attention to detail and rigorously cross-checks information. He seeks to strike a balance in his writing such that the regular reader gains an insight into player profiles, while also keeping in mind that the non-regular reader is not put off by jargon and shallow analysis.

Nikhil is an avid public speaker, and when not writing about baseball, he regularly participates in debates and quizzes.

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Edited by Ribin Peter

Yankees vs Red Sox: Game 1 prediction, odds, injuries and picks - June 6, 2025

Yankees vs. Red Sox Game 1: Betting Odds & Weather

Yankees vs. Red Sox Game 1: Injuries & Lineups

Injuries

Yankees

Red Sox

Expected Lineups

Yankees

Red Sox

Yankees vs. Red Sox Game 1: Prediction and Picks