Having lost just once this season - a 1-0 defeat to Slavia Prague on matchday two of this competition - Die Werkself have got off to a resounding start in the new campaign. They have won their last four games, including a 4-2 thumping of the Israeli outfit three weeks ago.
Leverkusen are now on six points in Group C, level with leaders Praha. Hapoel are at the bottom, with only three, and remain winless from their last six games in all competitions.
Bayer Leverkusen vs Hapoel Be'er Sheva Head-To-Head
The first leg between these sides at the start of the month was the first official game between them, which Leverkusen won 4-2 in Israel.
Bayer Leverkusen Form Guide (all competitions): L-W-W-W-W
Hapoel Be'er Sheva Form Guide (all competitions): L-D-L-D-L
Bayer Leverkusen vs Hapoel Be'er Sheva Team News
Leverkusen have quite a few injury concerns heading into the clash, with Paulinho, Santiago Arias, Charles Aranguiz, and Exequiel Palacios all sidelined with various issues. Edmond Tapsoba misses the match after testing positive for COVID-19.
However, the hosts will be bolstered by the return of Karim Bellarabi, who missed the last match due to a red-card suspension.
Injured: Paulinho, Santiago Arias, Charles Aranguiz, and Exequel Palacios
Unavailable: Edmond Tapsoba
Hapoel will be without the centre-back duo of Amit Bitton and Miguel Vitor, as well as winger Gal Levi, all of whom are out injured.
Injured: Amit Bitton, Miguel Vitor, and Gal Levi
Bayer Leverkusen vs Hapoel Be'er Sheva Predicted
Bayer Leverkusen (4-3-3): Lukas Hradecky; Lars Bender, Jonathan Tah, Sven Bender, Daley Sinkgraven; Florian Wirtz, Julian Baumgartlinger, Nadiem Amiri; Leon Bailey, Lucas Alario, Mousa Diaby.
Hapoel Be'er Sheva (3-4-3): Ohad Levita; Loai Taha, Eitan Ratzon, Marwan Kabha; Or Dadia, Josue, Mariano Bareiro, Sean Goldberg; Sintyahu Sallalich, Jhonatan Agudelo, Elton Acolatse.
Bayer Leverkusen vs Hapoel Be'er Sheva Prediction
Bayer Leverkusen's defence has been shaky, conceding 12 times in the last seven games, including five in this competition.
Despite their defensive issues, they've been able to pick up results due to the sheer amount of attacking firepower within their ranks. For that very same reason, we're predicting another win for Peter Bosz's side.
Prediction: Bayer Leverkusen 3-1 Hapoel Be'er Sheva