Manchester City will be looking to reach the fifth round of the FA Cup for a sixth straight year when they face Cheltenham Town at Whaddon Road on Saturday.Pep Guardiola's side have been relentless lately, winning their last nine games and going unbeaten in 16, stretching all the way back to November last year.During that period, they also dispatched Birmingham City 3-0 in the last round of this competition and are widely expected to extend their winning streak further.Cheltenham, the clear underdogs in this duel, have never beaten a Premier League side in eight previous attempts in the FA Cup. It is fair to say that they have a Herculean task on their hands.The Robins won't feel too inspired by their recent record either, winning just once from their last nine games in all competitions.That victory came in the last round of the competition when they saw off their League Two rivals Mansfield Town 2-1 in extra time.Cheltenham vs Manchester City Head-To-HeadThis will be the first ever competitive meeting between the sides.Michael Duff has labelled @CTFCofficial's @EmiratesFACup tie with Manchester City as "the biggest free hit in history" - by @nickmashiterhttps://t.co/iswi7YnFk0.— PA Dugout (@PAdugout) January 21, 2021Cheltenham Form Guide (all competitions): D-D-W-D-DManchester City Form Guide (all competitions): W-W-W-W-WCheltenham vs Manchester City Team NewsCheltenhamChris Hussey sustained an injury against Newport County on Wednesday and will be sidelined, while Elliot Bonds is also set to miss out. However, Sean Long is back in the squad and will be available for selection.Injured: Chris Hussey and Elliot BondsSuspended: NoneUnavailable: NoneSergio Aguero has announced he is self-isolating after testing positive for coronavirus.— Sky Sports News (@SkySportsNews) January 21, 2021Manchester CitySergio Aguero tested positive for COVID-19 and will hence miss the clash. Meanwhile, Aymeric Laporte has been sidelined since the start of the month.As much as Guardiola takes all competitions seriously, we expect him to make wholesale changes to his lineup, with most of the first-team stars rested.Injured: Aymeric LaporteSuspended: NoneUnavailable: Sergio AgueroCheltenham vs Manchester City Predicted XICheltenham (3-5-2): Joshua Griffiths; Charlie Raglan, Ben Tozer, William Boyle; Matty Blair, Chris Clements, Finn Azaz, Liam Sercombe, Lewis Freestone; George Lloyd, Alfie May.Manchester City (4-3-3): Zack Steffen; Joao Cancelo, Taylor Harwood-Bellis, John Stones, Benjamin Mendy; Tommy Doyle, Fernandinho, Bernardo Silva; Ferran Torres, Gabriel Jesus, Cole Palmer.Cheltenham vs Manchester City PredictionDespite all the changes that Guardiola is set to make, City will still have enough in the tank to cruise towards another routine win.Prediction: Cheltenham 0-4 Manchester City