The 2022 Copa Libertadores returns this week and will see Estudiantes host Nacional at the Estadio Ciudad de La Plata on Wednesday morning.Estudiantes have begun their continental campaign superbly. They picked up a comfortable 4-1 win over Velez Sarsfield in their first game before playing out a goalless draw against their midweek opponents in the reverse fixture. They returned to winning ways last time out, beating Red Bull Bragantino 2-0.The home side sit atop the group table with seven points from an obtainable nine. They will be looking to pick up maximum points on Wednesday as they set their sights on the knockout stages.Nacional picked up their first Copa Libertadores win of the season last week as they secured up a 2-1 comeback win over 10-man Velez Sarsfield. Emmanuel Gigliotti scored both goals for the visitors to end a run of back-to-back goalless outings in the competition. View this post on Instagram Instagram PostThe Uruguayan outfit sit third in the group with four points from three games. They will aim to pick up back-to-back continental wins when they play on Wednesday.Estudiantes vs Nacional Head-to-HeadThere have been six meetings between Estudiantes and Nacional. The hosts have won half of those games while the visitors have won once. There have been two draws between the sides, one of which came in their last meeting.Estudiantes Form Guide (All Competitions): W-W-D-W-WNacional Form Guide (All Competitions): W-W-D-D-WEstudiantes vs Nacional Team NewsEstudiantesMatias Pellegrini lasted 39 minutes against Red Bull Bragantino before picking up an injury. The winger will join Ezequiel Munoz on the injury list for the hosts.Injured: Ezequiel Munoz, Matias PellegriniDoubtful: NoneSuspended: NoneNacionalAlex Castro came off injured against Velez Sarsfield and is expected to miss Wednesday's game alongside Santiago Ramirez and Matias Zunino. Yonathan Rodriguez was another injury casualty last time out and may miss out on Wednesday's game.Injured: Santiago Ramírez, Matías Zunino, Alex CastroDoubtful: Juan Izquierdo, Renzo Sánchez, Yonathan RodriguezSuspended: NoneEstudiantes vs Nacional Predicted XIEstudiantes Predicted XI (4-4-2): Mariano Andujar (GK); Emanuel Tomás Beltrán Bardas, Fabian Noguera, Agustin Rogel, Leonardo Godoy; Mauro Boselli, Jorge Rodriguez, Fernando Zuqui, Manuel Castro; Gustavo del Prete, Leandro Diaz View this post on Instagram Instagram PostNacional Predicted XI (4-2-3-1): Sergio Rochet (GK); Jose Luis Rodriguez, Nicolas Marichal, Léo Coelho, Camilo Cándido; Felipe Carballo, Diego Rodriguez; Alfonso Trezza, Manuel Monzeglio, Brian Ocampo; Emmanuel Gigliotti$1,000 Risk-Free Bet at FanDuel SBEstudiantes vs Nacional PredictionEstudiantes are in strong form at the moment, going unbeaten in their last 12 games across all competitions. They have lost just one home game all year and will be relishing their chances ahead of the midweek clash.Nacional are on a five-game unbeaten run and have won their last three games on the road. They performed superbly in the reverse meeting and could pick up a point here.Prediction: Estudiantes 1-1 Nacional