Alex McCarthy (SOU) (£4.7 m) | Opponent: MUN (A): Alex McCarty produced some fine saves in a decent display against Aston Villa. He'll look to frustrate Manchester United at Old Trafford and get some FPL points.
Aaron Wan-Bissaka (MUN) - £5.4 m | Opponent: SOU (H): Aaron Wan-Bissakka put in a fine shift against Arsenal and was unlucky not to get some attacking FPL returns. He'll look to deliver both when Manchester United take on Southampton in Gameweek 22.
Matt Targett (AVL) - £4.6 m | Opponent: WHU (H): Matt Targett has produced an FPL return in each of his last four games and should carry on in the same vein in Gameweek 22.
John Stones (MCI)- £5.0 m | Opponent: BUR (A): After being rested in Gameweek 21, John Stones should step back into the heart of Man City's defence and get some clean sheet points for his FPL owners.
Son Heung-min (TOT) - £9.7 m | Opponent: CHE (H): Son and Spurs will look to make a comeback after their 1-0 loss to Brighton. He will look to get his name on the scoresheet and reward his FPL owners.
Raheem Sterling (MCI) - £11.5 m | Opponent: BUR (A): Sterling should be fit and fresh for City's Gameweek 22 meeting against Burnley, and he'll look to get some returns for his FPL owners.
Bruno Fernandes (MUN) - £10.9 m | Opponent: SOU (H): A home game against Southampton provides Fernandes with an ideal opportunity to break his dour run of games. He'll look to reward his FPL ownership with a stunning display against the Saints.
Mohamed Salah (LIV) - £12.5 m | Opponent: BHA (H): Salah returned to form with a stellar second-half display against West Ham in Gameweek 21. He's likely to be the most popular FPL captain in the Gameweek and should reward his FPL owners as well.
Ilkay Gundogan (MCI) - £5.7 m | Opponent: BUR (A): Gundogan was unlucky not to get any FPL returns against Sheffield United. He'll look to make an impact when City travel to Turf Moor in Gameweek 22.
Michail Antonio (WHU) - £6.3 m | Opponent: AVL (A): Michail Antonio couldn't make much of an impact against Liverpool. He will, however, look to find the net against Aston Villa and get some FPL points.
Ollie Watkins (AVL) (FWD) - £6.2 m | Opponent: WHU (H): Ollie Watkins missed some good chances on the way to a blank against Southampton. He'll aim to be more clinical against the Hammers.
GK: Fraser Forster (SOU) (£4.0 m) | Opponent: MUN (A)
1st Sub: Ben Chilwell (CHE)- £6.1 m | Opponent: TOT (A):
2nd Sub: Vladimir Coufal (WHU) - £4.6 m | Opponent: LIV(H):
3rd Sub: Keinan Davis (AVL) (FWD) - £4.3 m | Opponent: BUR (A):