The Swedish outfit produced an incredible comeback in Villarreal last week, fighting back from 3-1 down to hold the Bundesliga side to a pulsating 3-3 draw.
However, this actually tilts the balance in favor of the Die Kraichgauer, as they have three valuable away goals. Even a stalemate of any lower margin would be enough for them to progress.
But following last weekend's 4-0 win over Werder Bremen in the league, Sebastian Hoeness' team will be inspired to pull off a similar result here.
Molde have never progressed beyond this stage. In fact, their only ever appearance in the competition's knockout stage came back in 2015-16 season. On that occasion, they lost 3-1 on aggregate to eventual winners Sevilla.
So history isn't on their side, but Molde can be a huge menace if Hoffenheim fall asleep in defense once again.
Hoffenheim vs Molde Head-To-Head
Hoffenheim and Molde had never met in an official match before this year.
Hoffenheim Form Guide (all competitions): L-L-D-D-W
Molde Form Guide (all competitions): W-D-W-W-D
Hoffenheim vs Molde Team News
The hosts are currently reeling from a massive injury crisis, with as many as 10 players in the treatment room. Some of the injured include striker Ishak Belfodil, and long-term absentees Benjamin Hubner and Konstantinos Stafylidis.
Injured: Benjamin Hubner, Konstantinos Stafylidis, Ermin Bicakcic, Dennis Geiger, Kevin Akpoguma, Havard Nordtveit, Stefan Posch, Robert Skov, Ishak Belfodil, and Mijat Gacinovic.
Ola Brynhildsen is the only notable casualty for the visitors. The winger fractured his leg at the start of the month and won'r return before April.
Injured: Ola Brynhildsen
Hoffenheim vs Molde Predicted XI
Hoffenheim (3-4-1-2): Oliver Baumann; Kasim Adams, Kevin Vogt, Chris Richards; Pavel Kaderabek, Sebastian Rudy, Diadie Samassekou, Marco John; Christopher Baumgartner; Ihlas Bebou, Munas Dabbur.
Molde (4-4-2): Andreas Linde; Marcus Holmgren Pedersen, Martin Bjornbak, Stian Gregersen, Kristoffer Haugen; Mathis Bolly, Fredrik Aursnes, Martin Ellingsen, Eirik Ulland Andersen; Bjorn Sigurdarson, Magnus Wolff Eikram.
Hoffenheim vs Molde Prediction
Hoffenheim's leaky defense will be a cause of concern ahead of this match. However, they should have enough in their tank to defeat Molde and finish the job.
Prediction: Hoffenheim 2-1 Molde