Six-time Champions League winners Liverpool travel to Villarreal for the second leg of the 2021-22 season's semi-finals on May 3. The Reds displayed a promising performance in the first leg, registering a 2-0 win at Anfield on April 27.That being said, Unai Emery's Villarreal have come a long way, beating the likes of Juventus and Bayern Munich en route the semi-finals of the competition. They certainly won't make it easy for Liverpool, especially with the backing of the home fans.Emery claimed after the first leg that the Reds will suffer in the second leg, saying (via Talk Sport):“Obviously it’s very difficult. After they made it 2-0, you can go to try to score one goal. We tried but when they have space to do transitions and with the players like they have, it’s more important to try to do that next week at home. We’ll change something maybe tactically, but I think they are going to suffer more than tonight in the next leg.”Liverpool have an excellent chance of winning the Champions LeagueHaving already won the EFL Cup in February, the Reds are very much open to winning the remaining three trophies. They are in a good position in the Champions League, the Premier League (2nd) and the FA Cup (final). It would be a historic achievement for the Merseyside club if they manage to win an unprecedented quadruple.To register such a massive achievement, Liverpool have to first beat past Villarreal. A draw in Spain will help their cause but that is not what Jurgen Klopp will expect from his team. On that note, let's take a look at how the Reds could line-up against Villarreal.Formation: 4-3-3GK: Alisson BeckerLiverpool v Villarreal Semi Final Leg One - UEFA Champions LeagueThe Brazilian goalkeeper has been a key player for the Reds over the past few years. With his amazing shot-stopping abilities, Alisson Becker has come to Liverpool's rescue time and again.UEFA Champions League@ChampionsLeague🗣️ "Winning the Champions League is something special in a player's career. It is the best possible achievement for a club."@Alissonbecker | @LFC | #UCL1334105🗣️ "Winning the Champions League is something special in a player's career. It is the best possible achievement for a club."@Alissonbecker | @LFC | #UCLThe 29-year-old will definitely be starting against Villarreal and will be hoping to make a useful contribution in the second leg. Alisson has so far kept four clean-sheets in 13 matches in the Champions League this season.RB: Trent Alexander-ArnoldRB Leipzig v Liverpool FC - UEFA Champions League Round Of 16 Leg OneThe 23-year-old full-back is having a stellar season so far. Using his pin-point crossing abilities and attacking approach, Trent Alexander-Arnold has been very deadly on the right flank.UEFA Champions League@ChampionsLeaguePassing masterclass by Trent Alexander-Arnold @TrentAA | @LFC | #UCL4531446Passing masterclass by Trent Alexander-Arnold 🎯@TrentAA | @LFC | #UCL https://t.co/IqyJsYfpsMThe English right-back has provided two assists in the Champions League this campaign. It wouldn't come as a surprise if he adds one more to his tally in the second leg.CB: Ibrahima KonateIbrahima Konate has been in good goal-scoring formJurgen Klopp has shown a lot of faith in Ibrahima Konate, especially in big games. The French defender has capitalized on the opportunities given and has made it count.Konate has already scored twice in the Champions League and has been impressive defensively. He is expected to start ahead of Joel Matip in the second leg.CB: Virgil van DijkVirgil van Dijk will be crucial in the second legVirgil van Dijk has been a solid figure for Liverpool at the back. His strong and commanding defense has provided a lot of stability and security to his teammates.The Dutch defender will have to marshal the troops smartly in the second leg to prevent the match from slipping away. Virgil van Dijk has always come good for the Reds in high stakes games like these.LB: Andrew RobertsonAndy Robertson will be more adventurous on the leftLiverpool are blessed to have two amazing full-backs. Andrew Robertson has been absolutely amazing on the left with his attacking-minded and high-intensity approach.He will play a key role in unlocking the rigid Villarreal defense by stretching their defenders wide. Robertson is expected to be more productive in attack given the Yellow Submarine's defensive approach to the game.CDM: FabinhoLiverpool v Villarreal Semi Final Leg One - UEFA Champions LeagueFabinho is arguably one of the most underrated midfielders in the world right now. His calm and composed approach, combined with his defensive abilities, provides a lot of assurance in midfield.The Brazilian midfielder loves to get into tackles and win the ball back more often than not. Fabinho will have to play an important role in keeping Villarreal away from the Liverpool box.CM: Jordan HendersonHenderson is expected to lead the team to success in the semi-finalsJordan Henderson was subbed off early at the weekend in their 1-0 win in the Premier League against Newcastle United (April 30). With his experience, the English midfielder definitely has to start against Villarreal.Using his amazing passing range and vision, Henderson can control the tempo of the game. His leadership qualities will come in very handy when facing a tricky opposition like Villarreal.Henderson also made the first goal in the first leg as his cross was deflected into his own net by Pervis Estupinan.CM: Thiago AlcantaraThiago will be an improtant player in midfieldThe Spanish midfielder has some amazing skills under his belt. With his trickery, dribbling and creative abilities, Thiago Alcantara is an artist on the pitch.OptaJose@OptaJose103 - Thiago Alcántara attempted 103 passes against Villarreal (99 completed), his most in a single Champions League game for Liverpool. Master.37983103 - Thiago Alcántara 🇪🇸 attempted 103 passes against Villarreal (99 completed), his most in a single Champions League game for Liverpool. Master. https://t.co/gxyl9d5KfGHe can surely make things happen at his command and has been in good form lately. Thiago is likely to start ahead of Naby Keita and hopefully can contribute in attack using his playmaking abilities.RW: Mohamed SalahMohamed Salah has been in stellar form this seasonMohamed Salah is having a memorable season across all competitions. He is the fourth highest goal-scorer in the Champions League, with eight goals to his name.OptaJoe@OptaJoe7 - Mohamed Salah’s assist for Sadio Mané was the seventh time the pair have combined for a goal in the UEFA Champions League; the joint-most of any duo for English teams in the competition, equalling Wayne Rooney & Ryan Giggs and Mohamed Salah & Roberto Firmino. Synergy.29095187 - Mohamed Salah’s assist for Sadio Mané was the seventh time the pair have combined for a goal in the UEFA Champions League; the joint-most of any duo for English teams in the competition, equalling Wayne Rooney & Ryan Giggs and Mohamed Salah & Roberto Firmino. Synergy. https://t.co/H5XspGtE7pUsing his quick pace, mind-boggling dribbling and superb goal-scoring abilities, it has not been easy to contain Salah. The Egyptian will be looking to hurt Villarreal on the counter and try to kill the game as early as possible.LW: Luis DiazLuis Diaz has been a lively figure on the pitchThe Colombian is turning out to be a great signing for Liverpool since joining from Porto in January. Luis Diaz has looked quite impressive with his fine dribbling and productivity in front of goal.LiveScore@livescoreIn this season's UEFA Champions League, no player has won the ball in the final-third more than Liverpool's Luis Díaz #UCL11817In this season's UEFA Champions League, no player has won the ball in the final-third more than Liverpool's Luis Díaz 🇨🇴🔴⚡️#UCL https://t.co/MlG8ZGBmRsThe 25-year-old has already scored once and registered an assist in the Champions League this season. With Roberto Firmino struggling with his fitness, Diaz is most likely to start on the left wing against Villarreal.ST: Sadio ManeSadio Mane should start in a central positionThe Senegalese is once again having a great season with Liverpool. Sadio Mane has been one of the key goal contributors for the Reds this campaign.UEFA Champions League@ChampionsLeague Top scorers in the knockout stages for Liverpool (UCL era only): Sadio Mané Mohamed Salah Roberto Firmino Steven Gerrard Dirk Kuyt Luis García Fernando Torres #UCL6274797🔴 Top scorers in the knockout stages for Liverpool (UCL era only):⚽️1⃣4⃣ Sadio Mané⚽️1⃣1⃣ Mohamed Salah⚽️1⃣0⃣ Roberto Firmino⚽️0⃣6⃣ Steven Gerrard⚽️0⃣5⃣ Dirk Kuyt⚽️0⃣5⃣ Luis García ⚽️0⃣5⃣ Fernando Torres #UCL https://t.co/T4pMWm3WYjHis goal in the first leg gave his team a much-needed two-goal cushion. With already four goals to his name in the Champions League, Mane will be looking to increase his tally in the second leg.