Juventus were stunned 2-1 by Sassuolo in Serie A as Maxime Lopez struck an injury-time winner to pile more misery on the former champions. Davide Frattesi opened the scoring for Neroverdi in the dying moments of the first half before Weston McKennie equalised for the hosts midway through the second.
The game was headed for a draw, but Lopez capitalised on Juventus' calamitous defending. He broke into a counter before chipping over Mattia Perin for a 95th-minute winner.
Juventus had no time left to muster a response, losing to Sassuolo on home soil for the first time in their history. On that note. here are the five major talking points from the game:
#5 Juventus left to rue missed first-half chances
Given how the first half ended, no one really expected Juventus to lose this game. The hosts were absolutely dominant, controlling the ball and creating better chances, but poor finishing let them down.
Leonardo Bonucci fired a decent free-kick from Federico Chiesa wide off target early on before Dybala saw a shot come off the crossbar. Just minutes later, Chiesa joined the act too, but to no avail. He failed to maintain his composure, firing his effort into the stands.
That's three good chances gone begging inside the opening 38 minutes of the game. That was a real let-off for Sassuolo, who then immediately struck with the opener in the 44th minute.
#4 McKennie's goal masks another poor game for the star
The young American star won plaudits for bringing Juventus level with his first strike of the season, thumping home a fine header off Dybala's free-kick.
However, it masked an otherwise poor game he had on the night. Despite his goal, there has been a growing clamour that McKennie shouldn't start for Juventus regularly.
The 23-year-old looked off the pace and struggled to control midfield, getting dribbled past twice. His forward runs, though few and far between, didn't yield anything meaningful either. Both his crosses went begging, and he lost possession a staggering 14 times.
#3 Sassuolo create history
Sassuolo entered the game against Juventus without expecting to pick up all three points. That's because they had never beaten Juventus away from home in eight previous attempts.
In fact, the Neroverdi had beaten the Turin giants just once in 16 clashes against them, a narrow 1-0 victory in Emilia-Romagna back in October 2015.
So the odds were stacked firmly against them, but that didn't deter Alessio Dionisi's side from going all out at their mighty hosts. Their persistent efforts paid off towards the end of the first half. They weren't to be cowed down by McKennie's equaliser either, fighting on to find a late winner.
#2 Juventus were completely exposed on the break by Lopez
How Juventus conceded their second goal was truly comical yet shocking at the same time. Maxime Lopez had acres of space ahead of him to run into. He made no mistake, rounding off a fine counter-attack with an equally excellent lob over Mattia Perin.
The fact that McKennie was the only player in the Juventus half during that moment was ridiculous. Where was their backline? Not sure, but none of them were anywhere near Lopez, who comfortably made his way into the penalty area to finish the job.
It was an absolutely embarrassing defending sequence that exposed plenty of flaws that exist in the side, and not that it wasn't coming. Sassuolo had also found holes in Juventus' backline earlier in the game. Their winner was just reward for their efforts.
#1 Juventus nowhere near Scudetto material
Instead, the Italian's second term in charge of the club is becoming a nightmare. The Bianconeri are in a rut, struggling with patchy form and disappointing results.
Tonight was their third loss of the season in ten games, the most they've suffered at this stage of the season since 2015-16. Meanwhile, none of their four wins of the campaign have been impressive.
They now trail runaway leaders AC Milan by a massive 13 points, with Napoli also likely to open up an identical lead after their game tomorrow. That would leave Juventus with a huge early-season deficit to recover from. They nowhere look like title contenders at the moment.