Jose Mourinho will be looking for a response from his team after their listless performance in the 1-0 loss to Everton in their opening Premier League fixture.
After last season's sixth-placed finish, the successful Portuguese manager will be under pressure to deliver a trophy to the silverware-starved club and will view the Europa League as a good opportunity to do so.
Their opponents Lokomotiv Plovdiv belong to the First Professional Football League in Bulgaria and are also entering the midweek match on the back of a league defeat to Ludogorets.
With both teams looking to bounce back after a disappointing outing over the weekend, the match should possess an inviting edge to it.
For Jose Mourinho and his players, it is a must win should they harbour hopes of adding weight to Tottenham's trophy cabinet this season.
Lokomotiv Plovdiv vs Tottenham Head-to-Head
The clubs have not played each other yet. Thursday night's Europa League encounter will be the first time they do so.
Lokomotiv Plovdiv form guide: W-W-W-W-L
Tottenham form guide: W-W-W-L-L
Lokomotiv Plovdiv vs Tottenham Team News
Lokomotiv Plovdiv may be coming off a loss but there will be no doubts that the Bulgarian side, sitting fifth in the league, will relish the challenge of taking on Tottenham in midweek.
In fact, Plovdiv's chairman was quoted as saying, as soon as the draw was announced, that he was confident of his team's chances against Jose Mourinho's men.
It is a confidence that Plovdiv's coach Bruno Akrapovic apparently shares, as he too claimed he welcomes the challenge that Tottenham would pose.
Additionally, Lokomotiv Plovdiv has enjoyed a good run in home games this season, having won two out of two. They appear to be a fairly settled side, five games into their domestic league campaign.
Jose Mourinho has important decisions to make ahead of the match following a lacklustre performance against Everton in their opening Premier League fixture.
With Giovani Lo Celso possibly available to play after missing the weekend's game due to a thigh strain, the Portuguese tactician has to decide if he is fit enough to play the entire ninety minutes, or if necessity dictates it.
Alternatively, the game could also present the embattled Tanguy Ndombele a chance to earn some brownie points with Mourinho by putting in a solid shift.
Dele Alli was whisked off at half time against Everton after an anonymous showing. It will be interesting to see if he will start against Plovdiv too.
Japhet Tanganga is the only player definitely ruled out due to injury.
Injuries: Japhet Tanganga
Doubtful: Giovani Lo Celso
Lokomotiv Plovdiv vs Tottenham Predicted Lineups
Lokomotiv Plovdiv: Almeida; Vitanov, Salinas, Pugliese, Tsvetanov, Iliev, Karagaren, Ilic, Petrovic; Masoero, Lukov
Tottenham: Lloris, Doherty, Sanchez, Dier, Davies, Hojbjerg, Ndombele, Sissoko, Moura, Son, Kane
Lokomotiv Plovdiv vs Tottenham Prediction
On paper, this is definitely Tottenham's game to lose. Worryingly for Mourinho though, his side have made a habit of losing games they weren't meant to.
Expect him to field a full strength squad against Plovdiv. He will be all too aware that the hosts are up for the game.
The midweek Europa League fixture has all the makings of a riveting encounter but Mourinho, undoubtedly, will happily take a boring 1-0 win.
Prediction: Lokomotiv Plovdiv 1-2 TottenhamPublished 15 Sep 2020, 23:13 IST