The home side began their campaign with a dominant 4-1 victory against Sparta Prague, and will want to extend their stay at the top of the Group H table with another three points against Celtic.
Visitors Celtic lost their European season opener to Italian giants AC Milan 1-3, although they weren't as poor as the scoreline suggests.
With a number of key players out of action, Neil Lennon's side have struggled of late, and an away trip to Lille could potentially end in further disappointment.
Lille vs Celtic head-to-head
These two clubs have co-existed for well over 70 years, but this is the very first time they will lock horns with each other. The home side are one of the few teams in Europe to remain unbeaten in all competitions so far in the 2020-21 season, and have proven to be a tough nut to crack for most opposition clubs.
The visitors haven't experienced the joy of bagging full points in three consecutive games now, which all started with a painful derby defeat at home to arch rivals Rangers.
Their defensive issues were on full-display in their most recent game, a 3-3 draw against Aberdeen this weekend. Celtic desperately need a win not just to kickstart their Europa League campaign, but to rejuvenate their overall season.
LOSC Lille form: D-W-W-W-W
Celtic form: D-L-L-W-W
Lille vs Celtic team news
Christophe Galtier could make a few changes to the team that was held to a 1-1 draw by Nice this weekend.
Yusuf Yacizi could return to the starting line-up after only making the substitutes bench last time out. He netted a hat-trick against Sparta Prague and could be a handful against a weak Celtic defence. Young Canadian forward Jonathan David could also make the starting XI.
The away team have missed a number of first-team players due to one reason or another for the past few weeks.
Talismanic striker Odsonne Edouard has been out of action since testing positive for coronavirus while on national duty, but could finally return on Thursday evening. Nir Bitton and Hatem Abd Elhamed could also make their comebacks.
Injuries: Vasilis Barkas, Christopher Jullien, James Forrest
Doubtful: Hatem Abd Elhamed
Lille vs Celtic Predicted
Lille Predicted XI (4-4-1-1): Mike Maignan; Domagoj Bradarić; Sven Botman; Jose Fonte; Jérémy Pied; Yusuf Yazici; Xeka; Boubakary Soumaré; Jonathan Bamba; Nanitamo Ikone; Jonathan David.
Celtic Predicted XI (4-2-3-1): Scott Bain; Diego Laxalt; Jeremie Frimpong; Kristoffer Ajer; Shane Duffy; Oliver Ntcham; Scott Brown; Ryan Christie; Tom Rogic; Mohammed Elyounoussi; Odsonne Edouard.
Lille vs Celtic Prediction
Lille have started the season very strongly. They have been expressive with the ball, while solid at the back without it. The players are brimming with confidence, and although they did drop points in their most recent game, it is unlikely to halt their steady progress so far.
Celtic, on the other hand, have looked really shaky at the back of late. While they will be relieved to welcome some key figures back into the team, Lille should have enough quality to beat their Scottish opponents on Thursday.
Prediction: Lille 2-1 Celtic
Published 27 Oct 2020, 17:55 IST