Manchester City are back in action with another Premier League fixture this weekend as they take on Southampton on Saturday. The two teams have experienced contrasting fortunes this season and will want to win this game.Southampton are in 14th place in the Premier League standings at the moment and have not been at their best this season. The Saints held West Ham United to a 0-0 stalemate last week and will need to step up on Saturday.Manchester City, on the other hand, are back to their effervescent best in the Premier League and are edging towards the top four. Pep Guardiola's charges thrashed RB Leipzig in their previous game and will be confident ahead of this match.Manchester City@ManCityEnter below for your chance to win the new 21/22 #UCL training top! 🔥⬇️🔷 #ManCity | mancity.com7:23 AM · Sep 16, 202141314Enter below for your chance to win the new 21/22 #UCL training top! 🔥⬇️🔷 #ManCity | mancity.comManchester City vs Southampton Head-to-HeadManchester City have a good record against Southampton and have won 38 out of 95 matches played between the two teams. Southampton have managed 32 victories against the Cityzens and can trouble their opponents on Saturday.The previous game between the two teams took place in March this year and ended in a 5-2 victory for Manchester City. Southampton struggled on the day and have a point to prove this weekend.Manchester City form guide in the Premier League: W-W-W-LSouthampton form guide in the Premier League: D-D-D-LManchester City vs Southampton Team NewsManchester City hold the upper handManchester CityZack Steffen has tested positive for the coronavirus and will not be included in the squad for this game. Benjamin Mendy is currently in police custody and will not be able to feature in this match.Injured: NoneDoubtful: Aymeric Laporte, John StonesUnavailable: Zack Steffen, Benjamin MendySouthampton need to win this gameSouthamptonWilliam Smallbone, Stuart Armstrong, and Theo Walcott are injured at the moment and have been ruled out of this match. Shane Long has recovered from COVID-19 but might not be risked in this fixture.Injured: William Smallbone, Stuart Armstrong, Theo WalcottDoubtful: Shane LongSuspended: NoneManchester City vs Southampton Predicted XIManchester City Predicted XI (4-3-3): Ederson Moraes; Joao Cancelo, Ruben Dias, Nathan Ake, Kyle Walker; Rodri, Ilkay Gundogan, Kevin De Bruyne; Gabriel Jesus, Ferran Torres, Raheem SterlingSouthampton FC@SouthamptonFC🎫 Tickets for #SaintsFC's upcoming games against #LUFC and #BurnleyFC are now on general sale:3:32 AM · Sep 16, 2021795🎫 Tickets for #SaintsFC's upcoming games against #LUFC and #BurnleyFC are now on general sale:Southampton Predicted XI (4-2-3-1): Alex McCarthy; Kyle Walker-Peters, Mohammed Salisu, Jack Stephens, Valentino Livramento; Oriol Romeu, James Ward-Prowse, Mohamed Elyounoussi, Nathan Tella, Moussa Djenepo; Adam ArmstrongManchester City vs Southampton PredictionManchester City have excellent players in their ranks and will be intent on proving their mettle this season. Pep Guardiola's charges have registered three league victories on the trot and have been impressive in the final third.Southampton gave a good account of themselves last week but will need to play out of their skins in this game. Manchester City are the better team on paper and should be able to win this match.Prediction: Manchester City 4-1 Southampton