Fans on Twitter erupted after Manchester City lost the chance to cover ground on Arsenal as Pep Guardiola's team succumbed to a 1-0 defeat against Tottenham Hotspur. Spurs won the game with talismanic striker Harry Kane scoring the only goal of the game.The Cityzens had the chance to close the gap on Arsenal to two points as they made the trip to north London. The Gunners fell to a shock defeat against Everton in their latest Premier League clash.Guardiola's side, however, wasn't able to do so as the defeat means they remain five points behind the league leaders, having played one game more than Mikel Arteta's lot.Guardiola made a surprising decision as he didn't name Kevin De Bruyne in the team's first XI. While the defending champions managed to keep hold of the ball with their usual ease, they were unable to find the end product.Despite Erling Haaland and Julian Alvarez both starting against Spurs, Hugo Lloris remained unbeaten throughout the course of the game. The defeat marked the Cityzens' fourth in the league this season after 21 games.This is the fifth time the Cityzens have failed to score at Tottenham Hotspur Stadium. They have lost all five games at the arena.The game, meanwhile, marked a special occasion for Harry Kane as he became Spurs' all-time top scorer (267) with his goal. The Englishman has now also scored 200 Premier League goals.Here are some of the best reactions across Twitter after Manchester City's surprise Premier League away loss against Spurs:B/R Football@brfootballTottenham beating Manchester City but also helping Arsenal's title hopes in the process:3707565Tottenham beating Manchester City but also helping Arsenal's title hopes in the process: https://t.co/9BKYw7rlCoEuroFoot@eurofootcom Manchester City have now failed to score in the last 5 games at the Tottenham Hotspur Stadium!1313133❌🔵 Manchester City have now failed to score in the last 5 games at the Tottenham Hotspur Stadium! https://t.co/utCWaT7gFxReal Talk Manchester City@RealTalkMCFCMe watching City give away points again5516Me watching City give away points again https://t.co/Qpi8wFMr76PATRON 🇵🇸@Patron_MUFCManchester United fans this weekend. Arsenal, Liverpool and Manchester City all dropping points.8617Manchester United fans this weekend. Arsenal, Liverpool and Manchester City all dropping points. https://t.co/ry701VXY1FESPN UK@ESPNUKManchester City have played five games at the Tottenham Hotspur stadium.They've lost all five without ever scoring a goal 975137Manchester City have played five games at the Tottenham Hotspur stadium.They've lost all five without ever scoring a goal 😳 https://t.co/zczQx6x0KdManchester City@ManCityFULL-TIME | Defeat in North London.We'll pick ourselves up and go again next week 1-0 #ManCity1929318FULL-TIME | Defeat in North London.We'll pick ourselves up and go again next week 👍⚪️ 1-0 ⚫️ #ManCity https://t.co/GV4QPeGiKCFootball Daily@footballdailyManchester City's wait for a win at the Tottenham Hotspur stadium continues 598Manchester City's wait for a win at the Tottenham Hotspur stadium continues 💥⏰ https://t.co/oECLv5XfMJLe African Gooner@leafricangoonerWhen Tottenham Hotspur win but it’s against your title rivals Manchester City 17937When Tottenham Hotspur win but it’s against your title rivals Manchester City 😂 https://t.co/2vS9iIzPkOThe Athletic | Football@TheAthleticFCFT: Tottenham 1-0 Manchester City Harry Kane becomes #THFC's all-time leading goalscorer Striker becomes third player to score 200 Premier League goals Tottenham have won last four PL home games against #MCFC by an aggregate score of 6-0#TOTMCI10817FT: Tottenham 1-0 Manchester City⭐ Harry Kane becomes #THFC's all-time leading goalscorer⚽ Striker becomes third player to score 200 Premier League goals⚪ Tottenham have won last four PL home games against #MCFC by an aggregate score of 6-0#TOTMCI https://t.co/whi8Kj2B0c𝗧𝗲𝗻 𝗛𝗮𝗴’𝘀 𝗥𝗲𝗱𝘀 ✍🏼🇳🇱@TenHagBalITop weekend of football.Arsenal drop points.City drop points.Newcastle drop points.Manchester United gain 3pts. Brilliant stuff.91477Top weekend of football.Arsenal drop points.City drop points.Newcastle drop points.Manchester United gain 3pts. Brilliant stuff.😍 https://t.co/fWC7T5IVQLBen Jacobs@JacobsBenHuge win for Spurs (and Arsenal). Harry Kane scores the only goal in a 1-0 win over Manchester City and in doing so becomes Spurs' all-time record scorer (267) and reaches 200 Premier League goals.21423Huge win for Spurs (and Arsenal). Harry Kane scores the only goal in a 1-0 win over Manchester City and in doing so becomes Spurs' all-time record scorer (267) and reaches 200 Premier League goals.👏 https://t.co/Qi2cQVV3lYDanny Corcoran@calcio_dannyFive years of title races where Manchester City never slip up and now they do this as soon as we’re bad?15Five years of title races where Manchester City never slip up and now they do this as soon as we’re bad? https://t.co/AGMhueYoyXWelBeast@WelBeastIn case you were having a meltdown after Arsenal lost to Everton thinking Manchester City would win and close down the gap on Arsenal to 2 points, I'm here to remind you that Manchester City having played a game more, are still 5 points behind Arsenal. You're welcome.4209583In case you were having a meltdown after Arsenal lost to Everton thinking Manchester City would win and close down the gap on Arsenal to 2 points, I'm here to remind you that Manchester City having played a game more, are still 5 points behind Arsenal. You're welcome.Squawka@SquawkaManchester City have lost away to Spurs for the FOURTH consecutive time in the Premier League. And they still haven't scored at the Tottenham Hotspur stadium. 25676Manchester City have lost away to Spurs for the FOURTH consecutive time in the Premier League. And they still haven't scored at the Tottenham Hotspur stadium. 👀 https://t.co/Sy6gWkJz0mWhoScored.com@WhoScored🤯 Manchester City's record at the Tottenham Hotspur Stadium: 1-0 2-0 2-0 1-0 1-0 An unhappy hunting ground for Pep Guardiola...12124🤯 Manchester City's record at the Tottenham Hotspur Stadium:❌ 1-0❌ 2-0❌ 2-0❌ 1-0❌ 1-0😰 An unhappy hunting ground for Pep Guardiola... https://t.co/pmEbGE3MTZStatman Dave@StatmanDavePremier League sides to drop points this weekend:Arsenal Manchester City Newcastle Liverpool Chelsea Not a bad three days. 47659Premier League sides to drop points this weekend:Arsenal 🔴Manchester City 🔵Newcastle ⚫⚪Liverpool 🔴Chelsea 🔵Not a bad three days. 😉👹 https://t.co/8Yi5h7t5Z8𝐂𝐚𝐧𝐭𝐨𝐧𝐚'𝐬 𝐂𝐨𝐥𝐥𝐚𝐫@CantonasCoIIarLiverpool, Chelsea, Newcastle, Arsenal and Manchester City all dropped points this weekend.40133Liverpool, Chelsea, Newcastle, Arsenal and Manchester City all dropped points this weekend. https://t.co/ZrN4IHbgPhØdegaard Enthusiast 💭@AFCTempoEmerson Royal cashed in on his Cafu token against Manchester City… there’s tears of joy in my eyes804Emerson Royal cashed in on his Cafu token against Manchester City… there’s tears of joy in my eyes https://t.co/Kax0Hr47PI𝐀𝐅𝐂 𝐀𝐉𝐀𝐗 💎@TheEuropeanLadFT: Tottenham 1-0 Manchester City.1. Arsenal (50)2. Manchester City (45)3. Manchester United (42)4. Newcastle United (40)5. Tottenham (39)1944113FT: Tottenham 1-0 Manchester City.1. Arsenal (50)2. Manchester City (45)3. Manchester United (42)4. Newcastle United (40)5. Tottenham (39) https://t.co/ViEzJX0k6XMadima@MaanoMadimaSouth African Tourism acting CEO Themba Khumalo after Tottenham Hotspur scored against Manchester City:332124South African Tourism acting CEO Themba Khumalo after Tottenham Hotspur scored against Manchester City: https://t.co/40Jrs1vj3BFootball on BT Sport@btsportfootballDisappointment for Manchester City who fail to take advantage of Arsenal's defeat at Goodison Park.14715Disappointment for Manchester City who fail to take advantage of Arsenal's defeat at Goodison Park. https://t.co/XalL9eyP59The Coaches' Voice@CoachesVoiceCongratulations Cristian Stellini, who leads Tottenham to an impressive win over Pep Guardiola's Manchester City, in Antonio Conte’s absence.Solid defensive structure, effective high press and dangerous on the counter-attack. A performance Conte would be proud of. #THFC10911Congratulations Cristian Stellini, who leads Tottenham to an impressive win over Pep Guardiola's Manchester City, in Antonio Conte’s absence.Solid defensive structure, effective high press and dangerous on the counter-attack. A performance Conte would be proud of. 🇮🇹⚪️#THFC https://t.co/pfLRKUo8r6Alabi@the_LawrenzTottenham 1 - 0 Manchester city Arsenal Fans right now ;11122Tottenham 1 - 0 Manchester city Arsenal Fans right now ; https://t.co/W8XhEJIp5UWelBeast@WelBeastIf you have a problem with me, an Arsenal fan, supporting our rivals Tottenham Hotspur to beat Manchester City in order improve Arsenal's chances of winning the league title then go and drink bleach. I don't care.7071692If you have a problem with me, an Arsenal fan, supporting our rivals Tottenham Hotspur to beat Manchester City in order improve Arsenal's chances of winning the league title then go and drink bleach. I don't care.HT@half_turnSpurs helping Arsenal in a title race.. Written in the stars.23625Spurs helping Arsenal in a title race.. Written in the stars.Barstool Football@StoolFootballTOTTENHAM HAVE BEATEN MANCHESTER CITY TO STIR UP THE TITLE-RACE ONCE AGAIN! 🤯17613TOTTENHAM HAVE BEATEN MANCHESTER CITY TO STIR UP THE TITLE-RACE ONCE AGAIN! 🤯📈 https://t.co/k7p3Dpx2IqStatman Dave@StatmanDaveHarry Kane’s game by numbers vs. Manchester City:38 touches 4 ground duels won 2/2 long balls completed 2 shots on target 2 key passes1 goalPremier League legend. 🥇9812Harry Kane’s game by numbers vs. Manchester City:38 touches 4 ground duels won 2/2 long balls completed 2 shots on target 2 key passes1 goalPremier League legend. 🥇 https://t.co/bhTFGiGJ4ESuhail@SuhailChowdhary22 year old Erling Haaland has made Pep Guardiola’s Manchester City worst.5534622 year old Erling Haaland has made Pep Guardiola’s Manchester City worst.Statman Dave@StatmanDavePierre-Emile Hojbjerg’s game by numbers vs. Manchester City:100% dribbles completed 83% pass accuracy46 touches8 ball recoveries 5 ground duels won 3 tackles won 2 interceptions 1 key pass1 big chance created1 assistRan the midfield. 10817Pierre-Emile Hojbjerg’s game by numbers vs. Manchester City:100% dribbles completed 83% pass accuracy46 touches8 ball recoveries 5 ground duels won 3 tackles won 2 interceptions 1 key pass1 big chance created1 assistRan the midfield. 🏃 https://t.co/dZaCEdQpFfPierre-Emile Hojberg and Harry Kane stole the show for Tottenham against Manchester CitySpurs v Manchester City - Premier LeagueHarry Kane proved yet again why he is considered one of the best strikers ever in the Premier League with his performance against Manchester City. Apart from Kane, Pierre-Emile Hojberg was another player who ran the show for Tottenham. The Danish midfielder was the team's engine throughout the game.Guardiola's side will return to action on February 12 as they take on Aston Villa in a Premier League home clash. Spurs, meanwhile, will next take the trip to the King Power stadium to take on Leicester City in the league.