The German boss also described the Reds' supporters as 'wonderful people' and claimed they wouldn't boo anything if they didn't have a reason to.
Liverpool fans have long booed the national anthem whenever it has been played at Wembley. Fans audibly jeered the Duke of Cambridge, as well as the traditional Abide With Me hymn.
Supporters who have shown national apathy, particularly those who describe themselves as 'Scouse not English', have been lamented by fans and members of the British press.
Ahead of his side's trip to Southampton on Tuesday, 17 May, Klopp said at the pre-match press conference (as quoted by The Metro):
"Of course, I have thoughts but I think always in this sort of situation it is best to ask the question, Why did it happen? I know our people so well that they would not do it if there is not a reason for it. I have not been here long enough for sure to understand the reason.
"That’s for sure something historical and that’s probably a question you can answer much better than I can."
"I know some from other clubs see it slightly different but the majority of our fans are wonderful people, really smart. They understand, they go through lows and highs, suffer together. They wouldn’t do it if there was not a reason, that’s what I know. It was not something I enjoyed or whatever but that’s the answer."
Downing Street condemns Jurgen Klopp for defending Liverpool fans booing during national anthem
U.K. Prime Minister Boris Johnson has criticized Klopp for his comments regarding Liverpool fans booing the anthem and Prince William.
According to The Telegraph, a spokesperson for Johnson was asked after Klopp's comments whether the 54-year-old was right to defend supporters for their behavior before the cup final. The spokesperson replied 'no,' adding that it was a 'great shame' because the FA Cup should "bring people together."
The report also claims that Commons Speaker Lindsay Hoyle was prompted to 'utterly condemn any fans who booed Prince William.'
Liverpool are still on for a history-making quadruple this season after they defeated Chelsea on penalties in a cup final for the second time in three months.
The Reds' Premier League chances were boosted a day later when Manchester City were held 2-2 at West Ham. This means the title race could go down to the final day of the season.
Where does Mane rank in Paul Merson's 5 greatest Liverpool signings of the Klopp era? Click here