Manchester United and Cristiano Ronaldo suffered another blow in their pursuit of Champions League football next season after being held to a 1-1 draw by Southampton at Old Trafford.Ralf Rangnick's men were determined to bounce back from their draw against Burnley in their last outing, but ended up playing out the same scoreline on Saturday.Cristiano Ronaldo, who came on as a second-half substitute against Burnley, was restored to the starting line-up. However, the Portuguese forward endured a frustrating afternoon as he struggled to influence the game.Premier League@premierleagueA frantic and enthralling encounter finishes with the points shared#MUNSOU7:55 AM · Feb 12, 20224136464A frantic and enthralling encounter finishes with the points shared#MUNSOU https://t.co/8qhsQKfEaAThe Red Devils did start the game on the front foot and took the lead in the 21st minute. Jadon Sancho was on the scoresheet yet again as the summer-recruit netted hs first Premier League goal at Old Trafford. Bruno Fernandes played an excellent ball over the top for Marcus Rashford, who raced into the visitors' penalty box before squaring it to Sancho.Despite Kyle Walker-Peters' sliding effort to try and intercept, the ball made its way to Sancho. The Manchester United man's effort took a slight deflection off Walker-Peters and crashed into the back of the net as the home crowd erupted.Premier League@premierleagueLiving the dream @Sanchooo10 nets his first #PL goal at home for @ManUtd#MUNSOU6:29 AM · Feb 12, 20225975413Living the dream 😄💭@Sanchooo10 nets his first #PL goal at home for @ManUtd#MUNSOU https://t.co/zOJt3G2KMyAlthough the hosts enjoyed a rollicking start, Southampton grew in confidence as the game progressed. Ralph Hasenhuttl's men knocked on the door and were eventually rewarded shortly after the half-time interval.Che Adams slipped in behind the Manchester United defense after a pass from Mohamed Elyounoussi and restored parity for the visitors. The low shot from the Southampton striker with went in off the upright and left David De Gea with no chance of keeping it out.Cristiano Ronaldo missed a golden opportunity to give Manchester United an early leadEarlier, Cristiano Ronaldo had failed to find the back of the net despite rounding the goalkeeper as Romain Perraud came across to block his tame attempt. Manchester United also had a goal disallowed before half-time due to offside.Buoyed by the equalizer, Southampton continued to ask questions in the second half. Both Armando Broja and Stuart Armstrong conjured attempts to try and seal the win.Later, Cristiano Ronaldo found the back of the net with a header but his frustration was clearly visible when he looked up and saw the offside flag up against him. Harry Maguire was denied the opportunity to grab the winning goal in second-half stoppage time after an excellent save from Southampton shot-stopper Fraser Foster.The result now means Manchester United continue to sit outside the top-four in the Premier League in fifth place. On a rainy afternoon when Ronaldo failed to deliver the fireworks, Twitter was filled with reactions from across the globe.On that note, here are the best reactions from the game:Alex Shaw@AlexShawESPNRonaldo in that first half reminded me of Radamel Falcao.6:48 AM · Feb 12, 202248038Ronaldo in that first half reminded me of Radamel Falcao.Gary Lineker 💙@GaryLinekerGood to see @Sanchooo10 finally finding his feet that were so mesmerising at @BlackYellow 🏻6:26 AM · Feb 12, 20223954133Good to see @Sanchooo10 finally finding his feet that were so mesmerising at @BlackYellow 👍🏻Tim Land@Timbabaland1888How can anyone not think Ronaldo isn’t a problem in this United side7:06 AM · Feb 12, 2022How can anyone not think Ronaldo isn’t a problem in this United sideShxxy@ShayinnitRONALDO had only one job to do and he can't even do that 7:06 AM · Feb 12, 2022RONALDO had only one job to do and he can't even do that 💀 https://t.co/Avb6YgQU8tNickmeister@NiklauseXavierRonaldo shouldn't have came back the Premier League..He is so washed my God. #MUNSOU7:06 AM · Feb 12, 20222Ronaldo shouldn't have came back the Premier League..He is so washed my God. #MUNSOUFEMI 🇨🇦@belafeid_It's Feb 2022, and Cristiano Penaldo is yet register a goal or assist for his club..Lmaoo, can never be my GOAT!7:07 AM · Feb 12, 20222912It's Feb 2022, and Cristiano Penaldo is yet register a goal or assist for his club..Lmaoo, can never be my GOAT!Harikaran Pillai@HarikaranPillaiRollnaldo having a culture shock when he realized people in his team pass the ball #MUNSOU7:08 AM · Feb 12, 2022Rollnaldo having a culture shock when he realized people in his team pass the ball #MUNSOUᴴ@HaroIdCuntLuke Shaw when he's asked to step up:7:09 AM · Feb 12, 202214522Luke Shaw when he's asked to step up: https://t.co/jaflCCkHS9Miles Chappell@miles_chappellMan Utd vs Southampton highlights7:08 AM · Feb 12, 2022Man Utd vs Southampton highlights https://t.co/PZoEiIBtYJ⚽️442oons⚽️@442oonsMan United fans watching their team drop a lead for the third game in a row #MUNSOU7:09 AM · Feb 12, 202222622Man United fans watching their team drop a lead for the third game in a row 😭 #MUNSOU https://t.co/GAetfNR1SOFPL Amateurs of Aus (Quentin)@Fpl_Amateur_AusMan United's backline is looking great#FPL #FPLCommunity7:11 AM · Feb 12, 20222Man United's backline is looking great🔥#FPL #FPLCommunity https://t.co/4dNpEgTIkWً@UtdMicahLuke Shaw emptying his pockets tonight7:11 AM · Feb 12, 202281Luke Shaw emptying his pockets tonight https://t.co/6MCOzA1nA6Young Andrew@AnfrewAfellRonaldo looks so slow and stiff#MUNSOU7:07 AM · Feb 12, 20221Ronaldo looks so slow and stiff#MUNSOUTrey@UTDTreyEvery time the same shit, I'm tired7:08 AM · Feb 12, 20224386339Every time the same shit, I'm tiredHerbert Thiery@HerbertThieryPov : ure a man utd fans nowadays7:14 AM · Feb 12, 20222Pov : ure a man utd fans nowadays https://t.co/NsvSm86tzZGreat ovo@great_ovoThe messi PSG signed vs the ronaldo man utd signed7:14 AM · Feb 12, 2022The messi PSG signed vs the ronaldo man utd signed https://t.co/A1zKHFCPeHSwati Fella 🕴🏽@ThomasBlazinRonaldo’s English is good enough for MLS! Hollywood will save him from this embarrassment #MUNSOU7:14 AM · Feb 12, 20223Ronaldo’s English is good enough for MLS! Hollywood will save him from this embarrassment #MUNSOU https://t.co/tSKUAzypu5UtdBen 💎@UtdBen9Harry Maguire 2021/22 highlights7:14 AM · Feb 12, 202281Harry Maguire 2021/22 highlights https://t.co/ZkqAELHzMPWC@UTDbllrWatching Man United play football every week7:13 AM · Feb 12, 202218Watching Man United play football every week https://t.co/z4aMUp0pllThe Round Table Podcast@TRTablePodMan Utd fans once they hear the half time whistle7:13 AM · Feb 12, 20221011Man Utd fans once they hear the half time whistle https://t.co/MZ4V5SNBHCMason #ÖmerSZN@ReusTouch@slawoid Jadon Sancho at Manchester United7:12 AM · Feb 12, 202212@slawoid Jadon Sancho at Manchester United https://t.co/3Yxu7o5xXJebuka@neotheclutchRonaldo is not that guy anymore. The sooner he realizes it the better7:18 AM · Feb 12, 2022Ronaldo is not that guy anymore. The sooner he realizes it the betterً@tefo_breezyronaldo is washed7:18 AM · Feb 12, 20222ronaldo is washedKM💀@KeithMwandiaMKIt's time to let Ronaldo rest.7:18 AM · Feb 12, 2022It's time to let Ronaldo rest.