The Greek outfit registered a 2-0 win on aggregate against Neftci Baku in the last round. The second leg of the tie ended 1-0 in favor of Olympiacos, with Giorgos Masouras scoring the only goal of the game in the 15th minute.
Olympiacos begin their league campaign with a game against Atromitos on 21 August. They have won the league twice in a row and manager Pedro Martins will hope his side bag the top spot for the third year running.
Meanwhile, Ludogorets have already begun their league campaign. They are top of the table with six points, scoring six goals and conceding just one.
They reached the third round of qualification in the UEFA Champions League by overcoming Mura by a 3-1 aggregate scoreline.
Olympiacos vs Ludogorets Head-to-Head
The two teams have locked horns just once in a friendly match four years ago. The spoils were shared in a 1-1 stalemate.
Olympiacos form guide (Champions League): W-W
Ludogorets form guide (all competitions): W-D-W-W-W
Olympiacos vs Ludogorets Team News
Olympiacos have no injury or suspension concerns heading into Tuesday's contest.
The Greeks are expected to play a 5-4-1 formation, with Koka leading the line and Mathieu Valbuena and Giorgos Masouras likely to be deployed in wide areas.
New signings Kiril Despodov, Olivier Verdon, Igor Plastun and Bernard Tekpetey are all likely to feature in the Ludogorets starting XI against Olympiacos.
Ludogorets manager Valdas Dambrauskas has a fully-fit roster going into the game against Olympiacos.
Olympiacos vs Ludogorets Predicted XI
Olympiacos predicted XI (5-4-1): Konstantinos Tzkolakis; Kenny Lala, Ruben Semedo, Svetozar Markovic, Ousseynou Ba, Pape Abou Cisse; Mathieu Valbuena, Vasilios Sourlis, Pierre Kunde Malong, Georgios Masouras; Koka
Ludogorets predicted XI (4-3-3): Kristijan Kahlina; Jordan Ikoko, Igor Plastun, Olivier Verdon, Anton Nedyalkov; Cauly, Claude Goncalves, Alex Santana; Kiril Despodov, Pieros Sotiriou, Bernard Tekpetey
Olympiacos vs Ludogorets Prediction
Ludogorets have looked in good touch lately and should give Olympiacos good competition on their home soil on Tuesday. Olympiacos' cautious approach with a five-man backline might lead to a dour draw between the two sides.
We predict that the game between Olympiacos and Ludogorets will end 1-1.
Prediction: Olympiacos 1-1 Ludogorets
Where does Mane rank in Paul Merson's 5 greatest Liverpool signings of the Klopp era? Click here