Leipzig could only manage a 1-1 draw against Bayer Leverkusen last week, in a game that saw first-half goals from Kerem Demirbay and Emil Forsberg.
Schalke are a club in crisis, and sacked manager David Wagner earlier this week. They are 18 Bundesliga matches without a win, in a run that stretches back to January, and have conceded 11 goals in two games so far this season.
They started the season with a crushing 8-0 defeat against Bayern Munich at the Allianz Arena, and followed that up with a timid showing in a 3-1 defeat to Werder Bremen. Niclas Fullkrug scored a hat-trick for Bremen in a game that saw centre-back Ozan Kabak sent off for Schalke.
RB Leipzig vs FC Schalke 04 Head-to-Head
Lepizig have won four of their eight games against Schalke so far. They have only lost twice, with two games ending in draws.
RB Leipzig Bundesliga form guide: D-W
FC Schalke 04 Bundesliga form guide: L-L
RB Leipzig vs FSV Mainz 05 Team NewsRB Leipzig
RB Leipzig have Spanish attacking midfielder Dani Olmo ruled out with injury, along with the Austrian midfielder, Konrad Laimer. Ibrahima Konate also remains a doubt.
Injured: Dani Olmo, Fabrice Hartmann, Konrad Laimer, Ibrahima Konate
FC Schalke 04
If the horror start to their season was not bad enough, Schalke also have two leading midfielders and a centre-back ruled out due to injury. Suat Serdar and Omar Mascarell are both out, and Salif Sane remains a long-term absentee.
Kabak was sent off in the loss to Bremen and is suspended for this game.
Injuries: Omar Mascarell, Salif Sane, Suat Serdar
Suspensions: Ozan Kabak
RB Leipzig vs FC Schalke 04 Predicted XI
RB Leipzig Predicted XI (3-4-2-1): Peter Gulcasi; Lukas Klostermann, Dayot Upamecano, Willi Orban; Angelino, Tyler Adams, Kevin Kampl, Nordi Mukiele; Hee-Chan Hwang, Dani Olmo; Yussuf Poulsen
Schalke 04 Predicted XI (4-2-3-1): Ralf Fahrmann (GK); Sebastian Rudy, Benjamin Stambouli, Matija Nastasic, Bastian Oczipka; Nassim Boujellab, Nabil Bentaleb; Mark Uth, Amine Harit, Rabbi Matondo; Goncalo Pacienca
RB Leipzig vs FC Schalke 04 Prediction
You cannot see any result other than a Leipzig victory in this one. Schalke are mired in an absolute horror, and with Manuel Baum having to settle into the squad mid-season, this game is going to be a bridge too far for Schalke.
Prediction: RB Leipzig 3-0 FC Schalke 04