This will be the final game of the opening day and both sides will be keen to get the new campaign off to a winning start.
The home side finished the last campaign in ninth spot, while AC Milan finished as runners-up and consequently secured UEFA Champions League football for the first time since 2014.
The Rossoneri ended their pre-season campaign with a 2-1 victory over Greek side Panathinaikos last week, with new signing Olivier Giroud scoring both goals in the first half.
Sampdoria picked up a 3-2 home win over Serie B newcomers Alessandria in the Coppa Italia. Morten Thorsby scored the match-winner in the second half to complete a comeback victory for the hosts.
Sampdoria vs AC Milan Head-to-Head
AC Milan have 23 wins from their last 39 matches against Sampdoria. Eight previous matches ended in a share of the spoils - the same number of victories the Blucerchiati have to their name.
Their most recent meeting came in April when Jens Hauge stepped off the bench to snatch a late point for AC Milan in a 1-1 draw after Fabio Quagliarella had put the visitors ahead.
This will be AC Milan's first competitive game of the new season but the visitors have won just two of their five pre-season fixtures.
Sampdoria have already secured progress to the next stage of the Coppa Italia and their victory over Alessandria continued a fine run that saw them win all four pre-season fixtures.
Sampdoria form guide (including pre-season): W-W-W-W-W
AC Milan form guide (pre-season only): W-D-L-D-W
Sampdoria vs AC Milan Team News
The home side have no known injuries or suspension concerns. However, midfielder Fabio Depaoli will undergo a late fitness test to determine his availability.
Doubtful: Fabio Depaoli
Zlatan Ibrahimovic is yet to recover from the knee injury that sidelined him last season. Meanwhile, star midfielder Franck Kessie has also been ruled out with a hamstring injury.
Injuries: Franck Kessie, Zlatan Ibrahimovic
Sampdoria vs AC Milan Predicted XI
Sampdoria Predicted XI (4-2-3-1): Emil Audero (GK); Tommaso Augello, Julian Chabot, Jeison Murillo, Bartosz Bereszynski; Albin Ekdal, Morten Thorsby; Mikkel Dansgaard, Manolo Gabbiadini, Antonio Candreva; Fabio Quagliarella
AC Milan Predicted XI (4-4-2): Mike Maignan (GK); Theo Hernandez, Fikayo Tomori, Simon Kjaer, Davide Calabria; Rafael Leao, Rane Krunic, Sandro Tonali, Alexis Saelemaekers; Olivier Giroud, Ante Rebic
Sampdoria vs AC Milan Prediction
Sampdoria are one of the most attack-minded sides in the league and goalscoring chances are guaranteed to be created at both ends of the field.
The visitors are favorites in the game and we are predicting a narrow victory for AC Milan with both teams to get on the scoresheet.
Prediction: Sampdoria 1-2 AC Milan