The 2022 Copa Sudamericana makes its return this week and will see Santos host Union La Calera at the Urbano Caldeira on Wednesday as the two sides battle for a place in the knockout stages.Santos opened their continental campaign with a 1-0 loss to Banfield in early April. They bounced back from that to go unbeaten in their three subsequent outings in the competition, most recently beating Universidad Catolica de Ecuador 1-0 via a late winner from Rwan.The Brazilian outfit sit second in Group C with seven points from four games. They will now be looking to build on their latest result and leapfrog their midweek opponents with a win on Wednesday.Union La Calera have found better luck on the continental stage this season after their disappointing Copa Libertadores campaign last year. They have been undefeated in their four games so far and picked up a 1-0 victory over Banfield in their last game, with Sebastian Saez scoring the sole goal of the game. View this post on Instagram Instagram PostThe away team sit atop the group standings with eight points. They can confirm a spot in the knockout stages with a win here and will be looking to do just that.Santos vs Union La Calera Head-to-HeadWednesday's game will mark the second meeting between Santos and Union La Calera. The two teams faced off for the first time in the reverse fixture last month, playing out a 1-1 draw.Santos Form Guide (Copa Sudamericana): L-W-D-WUnion La Calera Form Guide (Copa Sudamericana): D-W-D-WSantos vs Union La Calera Team NewsSantosThe hosts are set to be without the services of Allanzinho, Jobson Tailson and Uruguayan international Carlos Sánchez as they are all injured.Injured: Allanzinho, Carlos Sánchez, Jobson, TailsonDoubtful: NoneSuspended: NoneUnion La CaleraManager Federico Vilar has no injury or suspension concerns ahead of Wednesday's game and will have all players in contention for selection.Injured: NoneDoubtful: NoneSuspended: NoneSantos vs Union La Calera Predicted XISantos Predicted XI (4-3-3): Joao Paulo; Madson, Emiliano Velazquez, Eduardo Bauermann, Felipe Jonatan; Rodrigo Fernandez, Vinicius Zanocelo, Willian Maranhao; Lucas Barbosa, Jhojan Julio, Brayan Angulo View this post on Instagram Instagram PostUnion La Calera Predicted XI (3-5-2): Ignacio Arce; Pedro Henrique, Christian Vilches, Erick Wiemberg; Esteban Cristobal, Thomas Rodríguez, Williams Alarcon, Gonzalo Castellani, Matias Fernandez; Sebastian Saez, Lucas PasseriniSantos vs Union La Calera PredictionSantos' latest result ended a three-game winning streak across all competitions and they will aim to bounce back from that. They are undefeated in their last seven home games and will be looking to capitalize on their home advantage this week.Union La Calera have had mixed results of late, picking up two wins, two draws and two losses in their last six games across all competitions. They have struggled to impress on the road this season and could lose here.Prediction: Santos 2-1 Union La Calera