| Sl.No | Pos. | Player | Age | Caps |
| 1 | Goalkeeper | Fernando Muslera | 32 | 107 |
| 2 | Goalkeeper | Martín Campaña | 30 | 3 |
| 3 | Goalkeeper | Martín Silva | 36 | 11 |
| 4 | Defender | José Giménez | 24 | 49 |
| 5 | Defender | Diego Godín (captain) | 33 | 126 |
| 6 | Defender | Giovanni González | 24 | 2 |
| 7 | Defender | Marcelo Saracchi | 21 | 4 |
| 8 | Defender | Diego Laxalt | 26 | 16 |
| 9 | Defender | Sebastián Coates | 28 | 34 |
| 10 | Defender | Martín Cáceres | 32 | 88 |
| 11 | Midfielder | Matías Vecino | 27 | 33 |
| 12 | Midfielder | Rodrigo Bentancur | 21 | 18 |
| 13 | Midfielder | Nicolás Lodeiro | 30 | 56 |
| 14 | Midfielder | Nahitan Nández | 23 | 22 |
| 15 | Midfielder | Giorgian De Arrascaeta | 25 | 19 |
| 16 | Midfielder | Lucas Torreira | 23 | 15 |
| 17 | Midfielder | Federico Valverde | 20 | 9 |
| 18 | Midfielder | Gastón Pereiro | 24 | 7 |
| 19 | Forward | Luis Suárez | 32 | 106 |
| 20 | Forward | Cristhian Stuani | 32 | 48 |
| 21 | Forward | Maxi Gómez | 22 | 11 |
| 22 | Forward | Jonathan Rodríguez | 25 | 14 |
| 23 | Forward | Edinson Cavani | 32 | 109 |
