After a rather disappointing draw away at Udinese in the weekend, La Viola returns to the Artemio Franchi for the first time since their thumping 7-1 win over the Giallorossi in the Coppa Italia.
With just seven points separating La Viola from the last Champions League spot, a win against Napoli could see them reducing the gap.
With Juventus playing a day later and going through a slight dip in form, Napoli has the chance to reduce the lead to just six points as the Gli Azzurri to keep their slender hopes of winning the Serie A alive for the first time since the days of Diego Maradona.
The last meeting between the sides ended with Gli Azzurri winning 1-0 at the San Paolo Stadium.
Stefano Pioli will be without key midfielder Marco Benassi and key defender Nikola Milenkovic, missing out through injury.
Victor Hugo and Vincent Laurini will face a late fitness test ahead of the match to determine their participation in the fixture.
Captain and all-time record goalscorer and appearance maker, Marek Hamsik has been left out of the squad due to an ongoing transfer to China failing to materialise.
Amin Younes and Vlad Chirches are also expected to miss out along with Raul Albiol who still yet to recover from injury.
Fiorentina(4-3-3): Lafont; Laurini, Pezzella, Hugo, Biraghi; Gerson, Fernandes, Veretout; Chiesa, Muriel, Pjaca
Napoli(4-4-2): Meret; Hysaj, Maksimovic, Koulibaly, Rui; Callejon, Fabian, Allan, Zielinski; Mertens, Insigne.Published 09 Feb 2019, 12:07 IST