Both Shakhtar and Inter started their 2021-22 UEFA Champions League campaigns on a disappointing note, losing to Sheriff Tiraspol and Real Madrid, respectively.
They will be looking to get back on the winning track and qualify for the knockout stages from a tricky group.
Shakhtar Donetsk are coming off a 4-1 win against Veres Rivne in the Ukrainian Premier League. Meanwhile, Inter Milan played out a 2-2 draw with Atlanta in their last league game on Saturday.
Shakhtar Donetsk vs Inter Milan Head-to-Head
Shakhtar Donetsk and Inter Milan have locked horns on five occasions, with the Ukrainian side yet to win a single game against the Italian heavyweights. Inter have won two matches, while three games have ended in draws.
The two sides played out a 0-0 draw the last time they met each other in the Champions League.
Shakhtar Donetsk form guide (all competitions): W-L-W-W-W
Inter Milan form guide (all competitions): D-L-W-W-D
Shakhtar Donetsk vs Inter Milan Team News
Junior Moraes is out with a ruptured cruciate ligament, while Dentinho and Fernando have been sidelined with injuries.
Injured: Junior Moraes, Dentinho and Fernando
Arturo Vidal continues to recover from a thigh problem, while Christian Eriksen has been ruled out due to a heart condition. Gabriel Brazao is out with a ligament rupture and Joaquin Correa will not be available for selection due to a bruised hip. Stefano Sensi is sidelined with a collateral ligament injury.
Injured: Arturo Vidal, Gabriel Brazao, Joaquin Correa, and Stefano Sensi
Unavailable: Christian Eriksen
Shakhtar Donetsk vs Inter Milan Predicted XI
Shakhtar Donetsk Predicted XI (4-2-3-1): Andriy Pyatov; Dodô, Vitão, Marlon, Mykola Matviyenko; Maycon, Alan Patrick; Tetê, Marcos Antonio, Manor Solomon; Lassina Traore
Inter Milan Predicted XI (3-5-2): Samir Handanovic, Stefan de Vrij, Milan Skriniar, Federico Dimarco, Denzel Dumfries, Nicolo Barella, Marcelo Brozovic, Hakan Çalhanoğlu, Ivan Perisic, Lautaro Martinez, Edin Dzeko
Shakhtar Donetsk vs Inter Milan Prediction
Despite enjoying success domestically, Shakhtar looked extremely vulnerable against Sheriff Tiraspol, and Inter presented a much bigger challenge. The Italians will be hungry for a win to put pressure on Real Madrid and should come away with all three points.
Prediction: Shakhtar Donetsk 1-2 Inter Milan
Also Check Out: Champions League Records