Die Werkself have won their last three games across all competitions, including a stunning 6-2 rout of Nice in the first group fixture. Leverkusen remain unbeaten in the 2020-21 season so far.
Peter Bosz's side are in a rich vein of form at the moment, but their Czech rivals are struggling with a poor run in Europe.
After going down 4-1 on aggregate to Midtjylland in the Champions League playoffs, Prague started off in this competition with a 3-1 loss to Hapoel Be'er Sheva.
Slavia Prague have proven to be a tough nut to crack. They have held top sides such as Barcelona, Inter Milan, and Sevilla to a draw in the last year.
Slavia Prague vs Bayer Leverkusen Head-To-Head
This is going to be the first official meeting between Slavia Prague and Bayer Leverkusen.
Slavia Praha Form Guide (all competitions): D-W-L-W-L
Bayer Leverkusen Form Guide (all competitions): D-D-W-W-W
Slavia Prague vs Bayer Leverkusen Team News
The Czech Republic champions do not have any fresh injury concerns, though full-back Tomas Holes and winger Peter Olayinka are still recovering from COVID-19 and will hence remain sidelined. Romanian international Nicolae Stanciu is pushing for a start.
Unavailable: Tomas Holes and Peter Olayinka
Leverkusen will continue to be without long-term absentees Paulinho, Patrick Schick, and Santiago Arias. Besides those individuals, there are no new casualties for Peter Bosz ahead of this encounter against Prau
Injured: Paulinho, Patrick Schick, and Santiago Arias
Slavia Prague vs Bayer Leverkusen Predicted XI
Slavia Praha (3-4-1-2): Ondrej Kolar; Ondrej Kudela, David Hovorka, Jan Boril; Tomas Malinsky, Oscar Dorley, Ibrahim Traore, Lukas Provod; Petr Sevcik; Stanislav Tecl, Petar Musa.
Bayer Leverkusen (4-1-4-1): Lukas Hradecky; Lars Bender, Sven Bender, Edmond Tapsoba, Wendell; Julian Baumgartlinger; Leon Bailey, Exequiel Palacios, Nadiem Amiri, Moussa Diaby; Lucas Alario.
Slavia Prague vs Bayer Leverkusen Prediction
Slavia Prague will be boosted by their break last weekend, in contrast to Leverkusen's domestic exertions against Augsburg less than 72 hours before the kick-off of this match.
However, there's no doubting the Bundesliga side's quality and squad depth, which should see them edge ahead in the tie.
Prediction: Slavia Prague 1-3 Bayer Leverkusen