Mikel Arteta's side are hoping to bounce back from three consecutive top-flight defeats. However, they will only go level on points with their arch-rivals Tottenham Hotspur with a win at Stamford Bridge. The Lilywhites are currently fourth and boast a superior goal difference to their north London rivals.
Following the announcement of the two starting lineups, it's fair to say Arsenal fans aren't particularly impressed with the players they have.
The Gunners have a number of injury problems, with first-team regulars such as Kieran Tierney, Thomas Partey, Takehiro Tomiyasu and Alexandre Lacazette all missing.
That means fringe players like Mohamed Elneny and Rob Holding will come in. Eddie Nketiah, who hasn't scored a single league goal this season, is leading the line.
Supporters have been quick to point out online that Arteta's makeshift team really highlights how thin their squad is. They took to Twitter to express their lack of confidence ahead of tonight's derby in the capital.
Here are some of the more pessimistic views from the Emirates faithful:
Arsenal desperate to stop their rot against Chelsea
By contrast, the Blues are aiming for their fourth consecutive victory, and will move eight points clear of fourth with a victory.
The Gunners lost the reverse fixture 2-0 in August. First-half goals from Romelu Lukaku and Reece James secured a comfortable victory for Thomas Tuchel's men at the Emirates Stadium.
However, tonight's visitors will take comfort in the fact that their recent record against Chelsea is pretty decent. The defeat earlier in the campaign was the Gunners' first against their London rivals in five games.
From being red-hot favorites for a top-four finish, the Gunners are now outsiders to claim the league's final Champions League spot. This comes following a disastrous fortnight in which they lost to mid-table teams Crystal Palace, Brighton and Southampton.