Manchester United's starting front three of Anthony Martial, Marcus Rashford and Mason Greenwood is amongst the best in Europe.
The young attack outscored the deadly front trio of Liverpool last Premier League season though they have started this one sluggishly.
To add to Manchester United's woes, Anthony Martial is suspended for the weekend while his replacement summer signing Edison Cavani is also likely to miss out due to COVID-19 protocols in the UK.
Dan James has fallen down the pecking order at Old Trafford following a bright start to his Manchester United life, and with Newcastle likely sitting deep his pace will not be needed much. While Jesse Lingard has shown no signs of getting back to his best as he continues to remain on the fringes of the squad.
Veterans Juan Mata and Odin Ighalo have been more than useful when it comes to Cup matches, with the former Chelsea player even winning the man of the match award in his last Cup start against Brighton. Despite their Cup form, Solskjaer seems to have little faith in them when it comes to the Premier League.
This leaves the Norwegian with Marcus Rashford and Mason Greenwood as the only two realistic options for starting places in the match against Newcastle.
He is therefore likely to abandon his preferred formation of 4-2-3-1 in favor of the 4-4-2 with the diamond in the middle, as his other forward options are just not attractive enough.
Rashford seems to be returning to top form with two club goals before the international break and another for England during it. His mojo looks to be returning as he is showing the willingness to take on defenders while on international duty.
He will be eager to rediscover his goal-scoring form from last season as United prepare to face a tough run of fixtures. His likely strike partner for the weekend - the young and talented Mason Greenwood - missed out on national selection due to off-field mistakes and will be motivated to prove his critics wrong.
Forwards: Rashford and Greenwood
Predicted XI: 4-4-2: David De Gea, Aaron Wan-Bissaka, Victor Lindelof, Harry Maguire, Alex Telles, Nemanja Matic, Paul Pogba, Bruno Fernandes, Donny van de Beek, Marcus Rashford and Mason Greenwood.