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The UEFA Champions League is still in its group stages but this is the tie one cannot miss. Manchester United face Juventus at their home, Old Trafford, after beating Young Boys convincingly in their first Champions League match before a draw with Valencia.
On the other hand, a much stronger and high flying Juventus will certainly relish the challenge of taking on United on their own turf. They have won both their previous Champions League matches and are on top of the group with six points.
"It is always a very important event to play against Manchester United," former Czech Republic midfielder Pavel Nedved, a former Juventus player and now a club vice-chairman, told BBC Sport. "This is going to be a fantastic match."
There is not a shred of doubt regarding how big the tie is, as both Manchester United and Juventus are two of football's biggest names. Let us quickly evaluate the reasons why football fans all over the world will keep an eye as United host Juventus on Tuesday night.
#3 Juventus and their quest for European glory
The last time Juventus won the UEFA Champions League was 22 years ago. They have appeared in the final two times in the last five years and lost both times, against Barcelona and Real Madrid.
But they hope, and have a strong belief that it will be different this time. They have strengthened their squad with the addition of Cristiano Ronaldo, who joined Juventus from Real Madrid last summer. This transfer also increased their financial muscle, but don't let the move hide the fact that Juventus are superb on all fronts. Their defence remains one of the best in Europe and looks almost impenetrable at times.
They have won seven consecutive league titles in Italy but European domination remains elusive. It is evident with their transfer activities that they are hungrier than ever in their quest for the Champions League.
#2 It's a pivotal time for Jose Mourinho's Manchester United
Jose Mourinho's third season with his previous club were not at all successful, and marked with controversies. A poor start to the English Premier League and alleged rifts with star players like Paul Pogba have only added to Mourinho's woes. They are languishing 10th in the league, and United desperately need motivation to improve as the season goes on.
But his team seemed to have gained some form when they came back from a 2-0 deficit against Newcastle United to win the match, and held a high flying Chelsea to a 2-2 draw. There is no doubt that Jose Mourinho would like his players to continue the good form against the mighty Juventus.
Moreover, their UEFA Champions League standing is not convincing enough, though they are second in their group. Valencia are third, and they face Young Boys and so United will expect them to pick up all three points. Another loss will surely add more fire to the rumours linking Mourinho with the sack.
#1 Cristiano Ronaldo's homecoming
The real headline leading up to this match is the return of Cristiano Ronaldo to the club he played for prior to joining Real Madrid. He will obviously receive a positive response from the Manchester United fans, after serving them for almost six years.
There is no doubt about Cristiano Ronaldo being a huge crowd favourite with the Manchester United fans. He won everything there is to win with Manchester United - from Premier League titles, Champions League to Ballon d'Or - and was key to United's success from 2006-09 where he scored around 90 goals in these three seasons.
Cristiano's relationship with Manchester United and with the likes of Sir Alex Ferguson has always been positive and received a hero's welcome when he faced United in his Real Madrid days. He scored 118 goals in 292 appearances for the club, and it will be interesting to see how he performs tonight.
