Tottenham Hotspur entertain Rennes at the Tottenham Hotspur Stadium looking to confirm their place in the knockout playoffs of the UEFA Europa Conference League.Rennes have 11 points from their five games and have secured a passage into the round of 16 while Tottenham Hotspur and Vitesse both have seven points and are in contention for second spot in Group G.Tottenham suffered their first defeat of the campaign at the hands of Mura in their previous outing but have recorded back-to-back wins in the Premier League since. Rennes are unbeaten in the competition and bounced back from a 1-2 loss at Lille with a 5-0 win over Saint Etienne on Sunday.Despite the fact that at least six first-team players from Tottenham Hotspur tested positive for COVID-19, UEFA has confirmed that the game will go ahead as planned.UEFA Europa Conference League@europacnfleagueTottenham OR Vitesse: who'll take second place? 🤔#UECL1:30 AM · Dec 7, 202133723Tottenham OR Vitesse: who'll take second place? 🤔#UECLTottenham Hotspur vs Rennes Head-to-HeadThis is just the second competitive meeting between the two sides. They last squared off at Roazhon Park in September. The spoils were shared in that game as both sides scored one goal in either half.Tottenham Hotspur form guide (all competitions): W-W-L-W-DRennes form guide (all competitions): W-L-W-D-WTottenham Hotspur vs Rennes Team NewsTottenham HotspurCristian Romero is a major absentee for the hosts as the hamstring injury he picked up in the international break is expected to keep him out until February.There has been an outbreak of COVID-19 cases at the club and as per initial reports, as many as six players have tested positive. More PCR testing is due to take place over the next 24 hours. Romero was also one of the players who tested positive.Here are the rest of the absentees for Spurs: Emerson Royal - COVID-19Son Heung-min - COVID-19Lucas Moura - COVID-19Ben Davies - COVID-19Bryan Gil - COVID-19Sergio Reguilon - Muscle strainGiovani Lo Celso - Knee injuryRyan Sessegnon picked up two yellow cards in the loss to Mura and is suspended for the game.Tottenham Hotspur@SpursOfficialThis week. 👇𝗧𝗵𝘂𝗿𝘀𝗱𝗮𝘆: Stade Rennais (H)𝗦𝘂𝗻𝗱𝗮𝘆: Brighton (A)We move forwards - together. 👊8:02 AM · Dec 6, 20213484113This week. 👇𝗧𝗵𝘂𝗿𝘀𝗱𝗮𝘆: Stade Rennais (H)𝗦𝘂𝗻𝗱𝗮𝘆: Brighton (A)We move forwards - together. 👊 https://t.co/loL76LU0CfInjury: Cristian Romero, Sergio ReguilonDoubtful: Giovani Lo CelsoSuspension: Ryan SessegnonUnavailable (COVID-19): Emerson Royal, Bryan Gil, Son Heung-min, Lucas Moura, Ben DaviesRennes Flavien Tait and Jérémy Doku were absent in the squad against Saint Etienne and are doubts for this game as well. They face a late fitness test ahead of their trip to London. Here are the other absentees for Les Rennes: Jeremy Gelin - ACL injuryInjury: Jeremy GelinDoubtful: Flavien Tait, Jérémy DokuSuspension: NoneTottenham Hotspur vs Rennes Predicted XITottenham Predicted XI (3-4-2-1): Hugo Lloris; Davinson Sánchez, Eric Dier, Joe Rodon; Matt Doherty, Harry Winks, Pierre-Emile Hobjberg, Japhet Tanganga; Dele Alli, Steven Bergwijn; Harry KaneRennes Predicted XI (4-3-3): Alfred Gomis; Adrien Truffert, Nayef Aguerd, Warmed Omari, Hamari Traore; Jonas Martin, Kamaldeen Sulemana, Baptiste Santamaria; Benjamin Bourigeaud, Martin Terrier, Gaetan LabordeTottenham Hotspur vs Rennes PredictionRennes would've been a tough test for Tottenham Hotspur even with a fully-fit squad, so a depleted squad for this game might struggle against the in-form Ligue 1 side.Antonio Conte's men are expected to fall short against the visiting side, who've enjoyed a good run in their recent outings.Prediction: Tottenham Hotspur 1-2 Rennes