Liverpool were title favourites earlier in the season, but have gone through a rough patch since the turn of the year. The Reds have lost their last two games, including a 3-2 defeat to Manchester United in the FA Cup.
Jose Mourinho's Tottenham side also looked like contenders in the title race earlier in the season, but have since faltered.
Spurs are one point behind Liverpool in sixth with a game in hand over the Reds. Tottenham have seen an uptick in their form recently, going unbeaten in eight games across all competitions.
Thursday's clash could be make-or-break for Liverpool, as a loss could see them fall to as low as sixth at the end of this round of fixtures.
Jurgen Klopp will need to find a way to get past a resurgent Tottenham side, but will know that Mourinho's men are dangerous enough to cause havoc to the Reds' weakened backline.
Tottenham vs Liverpool Head-to-Head
If their recent head-to-head record is anything to go by, Liverpool should be confident going into this fixture. The Reds are unbeaten against Tottenham in the last three seasons, including a 2-0 win the Champions League final in 2019.
Liverpool have won eight of the last 10 meetings between the two sides, with their only loss coming back in 2017.
Jurgen Klopp will hope that Thursday's clash will follow suit, and that his side can come away from London with all three points in the bag.
Tottenham Form Guide: W-W-D-W-W
Liverpool Form Guide: L-W-D-L-L
Tottenham vs Liverpool Team News
Jose Mourinho will have Serge Aurier available for selection again. The Ivorian was an unused substitute for Tottenham's FA Cup clash against Wycombe. He will most likely take part against Liverpool.
Matt Doherty's participation is still in doubt after missing the game against Wycombe due to an unspecified injury. Giovani Lo Celso and Dele Alli will not take part against Liverpool, as both midfielders are still injured.
Injured: Giovani Lo Celso, Dele Alli
Doubtful: Matt Doherty
Jurgen Klopp's side is still ravaged by injury, especially in defence, where they will be missing their centre-back duo of Virgil van Dijk and Joe Gomez. Diogo Jota and Naby Keita will also miss the game through injury.
Liverpool will hope to have skipper Jordan Henderson back for the game, after the midfielder missed Liverpool's last two games. The Englishman's involvement on Thursday still remains in doubt.
Injured: Virgil van Dijk, Joe Gomez, Diogo Jota, Naby Keita
Doubtful: Jordan Henderson
Tottenham vs Liverpool Predicted XI
Tottenham Predicted XI (4-2-3-1): Hugo Lloris; Sergio Reguillon, Eric Dier, Davinson Sanchez, Serge Aurier; Pierre-Emile Hojbjerg, Harry Winks; Heung-min Son, Tanguy Ndombele, Steven Bergwijn; Harry Kane
Liverpool Predicted XI (4-3-3): Alisson; Andy Robertson, Fabinho, Joel Matip, Trent Alexander-Arnold; Thiago Alcantara, Georginio Wijnaldum, Xherdan Shaqiri; Sadio Mane, Mohammed Salah, Roberto Firmino
Tottenham vs Liverpool Prediction
Liverpool really need a win on Thursday, and the Reds will be looking for a quick start to the game. However, Jose Mourinho's side are adept at soaking up the pressure and catching teams on the counter-attack.
Tottenham should have too much for a weakened Liverpool to handle.
Prediction: Tottenham 3-1 Liverpool