Manchester United suffered a shock 1-0 defeat at the hands of Aston Villa at Old Trafford on Saturday in the Premier League. The Red Devils were determined to conjure up a strong reaction after their League Cup debacle on Wednesday, but were instead handed another blow. Ole Gunnar Solskjaer named a strong line-up by restoring several key personnel, including Cristiano Ronaldo and Bruno Fernandes, into the playing eleven. Dean Smith's Villa were not overwhelmed by the task of handling a star-studded Manchester United team though. The visitors stuck to their guns and secured a famous win, thanks to a bit of luck in the end.Kortney Hause, who made his first league start for Villa this season, opened the scoring against Manchester United in the 88th minute. The Englishman was on the receiving end of a corner from team-mate Douglas Luiz as he fired in a header to break the deadlock and send the Villa fans into an uproar.However, it seemed like Hause would go from hero to zero when he was penalized in the dying embers of the game. With help from VAR, referee Mike Dean adjudged Hause to have handled the ball and Fernandes stepped up to take the penalty.Usually reliable from the spot, Fernandes uncharacteristically fired his spot-kick over the bar at the Stretford End. Villa breathed a collective sigh of relief and Manchester United were left in agony for missing the golden opportunity that came their way.Manchester United slip to fourth in points table after defeatFollowing the defeat, Manchester United slipped to fourth in the Premier League table. Fortunately for the Red Devils, rivals Chelsea also suffered a 1-0 defeat to Manchester City, meaning they continue to remain within touching distance of the Blues.However, Liverpool can now open up a three-point gap at the summit of the table if they win against newly-promoted Brentford later tonight. Meanwhile, Aston Villa climbed to seventh in the table with their win. Dean Smith's side have now won consecutive games in the Premier League and have another daunting trip to come in their next outing. Villa are scheduled to meet Tottenham Hotspur next weekend, with Manchester United facing Everton. Ever since Fernandes' ill-fated penalty sailed over the cross-bar, Twitter has been filled with hilarious reactions from around the globe. Without further delay, let's take a closer look at some of the best responses after Manchester United slipped to defeat in their own backyard:KALYJAY@gyaigyimiiNice Penalty by Bruno. #MUNAVL7:10 AM · Sep 25, 20211104348Nice Penalty by Bruno. #MUNAVLhttps://t.co/brOcVBJstq⚽️442oons⚽️@442oonsBruno Fernandes penalty has finally landed #MUNAVL6:58 AM · Sep 25, 2021878144Bruno Fernandes penalty has finally landed #MUNAVL https://t.co/gvHpl7MJNkTyriq Murugan@moujapesoesSAF tweeting #OleOut from his burner account.#MUNAVL6:45 AM · Sep 25, 202130168SAF tweeting #OleOut from his burner account.#MUNAVL https://t.co/Qx3TN5extGE@iamOkonRonaldo and the rest of the Man United squad chasing Bruno Fernandes after his penalty miss against Aston villa. 🤣 #MUNAVL6:57 AM · Sep 25, 2021327150Ronaldo and the rest of the Man United squad chasing Bruno Fernandes after his penalty miss against Aston villa. 🤣 #MUNAVLhttps://t.co/8gAeIEk4vuAmazon Prime Video Sport@primevideosportEmi Martinez danced in front of Man Utd's fans straight after Bruno Fernandes missed his penalty...#MUNAVL8:06 AM · Sep 25, 202143237Emi Martinez danced in front of Man Utd's fans straight after Bruno Fernandes missed his penalty...#MUNAVL https://t.co/NxZmABlZiPJas K@ChesterkopMe dog is still looking 4 bruno's penalty 😂😂😂😂😂 #MUNAVL7:09 AM · Sep 25, 202111711Me dog is still looking 4 bruno's penalty 😂😂😂😂😂 #MUNAVL https://t.co/o7ujjCR1WCVic@vickerdiha_Man United signed the likes of Ronaldo, Sancho, Verane this summer and still have the likes of Pogba, Fernandes, Greenwood, Cavani and Rashford in their squad, but still...OLE'S AT THE WHEEL...😂#MUNAVL #MUFC #OleOut7:15 AM · Sep 25, 202138996Man United signed the likes of Ronaldo, Sancho, Verane this summer and still have the likes of Pogba, Fernandes, Greenwood, Cavani and Rashford in their squad, but still...OLE'S AT THE WHEEL...😂#MUNAVL #MUFC #OleOut https://t.co/QXPWw6YwoLBetter Call Salah@dineshchoudh4ryAtleast we won a penalty, eh?#MUNAVL8:33 AM · Sep 25, 202111Atleast we won a penalty, eh?#MUNAVL https://t.co/VtjhlcpEqISherilyn@sherilynckyWho did this!? 🤣🤌🏻 #MUNAVL8:32 AM · Sep 25, 2021Who did this!? 🤣🤌🏻 #MUNAVL https://t.co/rpYVgvqeY0Adołf Drįplér™️@Fab_1016Me looking for the ball to land from Bruno’s pen 😂😂😂 #MUNAVL8:43 AM · Sep 25, 2021Me looking for the ball to land from Bruno’s pen 😂😂😂 #MUNAVL https://t.co/hcFA2m0D89Mr. Os 🧘🏾‍♂️ (El Abochieno)@abochie_Breaking News 🚨: Bruno Fernandes penalty, smashed Ole’s car outside Old Trafford stadium.. 😱😱 #MUNAVL #OleOut8:10 AM · Sep 25, 202115557Breaking News 🚨: Bruno Fernandes penalty, smashed Ole’s car outside Old Trafford stadium.. 😱😱 #MUNAVL #OleOut https://t.co/cX9W8SSLogAkshat Malik@akshatmalikWhen You Have The Greatest Penalty Taker in Your Team, You let him take the Penalty. It's simple.#MUNAVL #Ronaldo #Penalty8:49 AM · Sep 25, 2021When You Have The Greatest Penalty Taker in Your Team, You let him take the Penalty. It's simple.#MUNAVL #Ronaldo #Penalty https://t.co/DKJ6YHFORIVAR ❁@ZiyechmanOle's achievements so far 👏 #OleOut7:07 AM · Sep 25, 20211228330Ole's achievements so far 👏 #OleOut https://t.co/RNWXMLIxePCaleb ⛷@mufcaleb“You think if we play shit we can get Ole sacked?” #oleout7:07 AM · Sep 25, 2021784181“You think if we play shit we can get Ole sacked?” #oleout https://t.co/K8ZLPsJQdyEduardo Hagn@EduardoHagnHe was telling Cristiano to kick the penalty… unreal.7:18 AM · Sep 25, 202188411633He was telling Cristiano to kick the penalty… unreal. https://t.co/zkSJhghG5Wmikey LFC YNWA #JFT97 ⚽️🔴@mikeywa19388741Minding my own business in me garden. Then get hit on the head from what i can only think is the ball from bruno fernandes penalty miss😂😂. #Shitpenalty.8:53 AM · Sep 25, 20211Minding my own business in me garden. Then get hit on the head from what i can only think is the ball from bruno fernandes penalty miss😂😂. #Shitpenalty. https://t.co/z7Fo9jRdDWKloppNights@StopRodgersOutAny #ManUtd fans want to buy a match ball? I’ve got the one Bruno kicked here in The Netherlands..#MUNAVL8:55 AM · Sep 25, 20212Any #ManUtd fans want to buy a match ball? I’ve got the one Bruno kicked here in The Netherlands..#MUNAVLsilaw sang@silaw_sangSKY IS THE LIMIT! #MUNAVL8:55 AM · Sep 25, 20211SKY IS THE LIMIT! #MUNAVL https://t.co/Y9a41sOqEgBoring James Milner@BoringMilnerBruno Fernandes' penalty just landed in my back garden.6:55 AM · Sep 25, 202166941231Bruno Fernandes' penalty just landed in my back garden.PurelyFootball@PurelyFootballCristiano Ronaldo next time Bruno Fernandes asks to take a penalty…7:11 AM · Sep 25, 20211571159Cristiano Ronaldo next time Bruno Fernandes asks to take a penalty… https://t.co/QHLSdIgxNS⭐️ ⭐️ ⭐️ ⭐️ ⭐️ ⭐️@L30NIDA_PE teacher having a go at Klopp for not getting pens. Today his golden boy skies a pen to lose at home 😂😂😂 You can’t make this sh*t up.#MUNAVL8:55 AM · Sep 25, 2021PE teacher having a go at Klopp for not getting pens. Today his golden boy skies a pen to lose at home 😂😂😂 You can’t make this sh*t up.#MUNAVL⚽️442oons⚽️@442oonsWhen you realise Ronaldo will never let you take a penalty ever again #MUNAVL6:54 AM · Sep 25, 20211370238When you realise Ronaldo will never let you take a penalty ever again #MUNAVL https://t.co/jtuWWFBsMmyole ♛ 😎❤️@distracteduRonaldo going to meet Greenwood and Bruno after the game #MUNAVL7:01 AM · Sep 25, 202151094Ronaldo going to meet Greenwood and Bruno after the game #MUNAVL https://t.co/MGGlVduwRGmoyne.@revengemoyneMason Greenwood today #MUNAVL #MUFC6:53 AM · Sep 25, 202121561Mason Greenwood today #MUNAVL #MUFC https://t.co/NErC3mgDvyFPL Captain@CaptainOfFPLThe ball waiting for Bruno outside the stadium #MUNAVL7:02 AM · Sep 25, 202177The ball waiting for Bruno outside the stadium #MUNAVL https://t.co/aHeFztUuiLRüzgar🚬@ruzgar1903HFred controlling the ball #MUNAVL5:36 AM · Sep 25, 20213312Fred controlling the ball #MUNAVL https://t.co/iRDtmIndH3Ahmad@ahmad_gooner7BRUNO HIGHLIGHTS AGAINST VILLA#MUNAVL6:59 AM · Sep 25, 202112BRUNO HIGHLIGHTS AGAINST VILLA#MUNAVL https://t.co/gY8bu2s8Ne