Cristiano Ronaldo and Manchester United were pushed into further misery on Saturday when Watford secured a shock 4-1 win over them in the Premier League. Ole Gunnar Solskjaer's men were second-best for the majority of the game and have now lost five of their last seven league games. The Red Devils started off on the worst possible note as Scott McTominay conceded a penalty early on. However, David de Gea produced a stunning double save to deny Ismaila Sarr. The Hornets eventually grabbed the lead in the 28th minute through Josh King, who sidefooted his finish past De Gea after a cross from Emmanuel Dennis. While the opening goal stemmed from a weak clearance from Aaron Wan-Bissaka, the second was a result of Manchester United failing to clear their lines collectively. Sarr managed to get on the end of a pass from Kiko Femenia and drilled his shot past De Gea. Manchester United entered the half-time interval two goals behind the hosts and it felt like there was no coming back for them. Solskjaer responded by introducing Donny van de Beek and Anthony Martial ahead of the second half. It seemed like Manchester United could turn things around when Van de Beek scored just minutes after coming on. Jadon Sancho delivered an inch-perfect cross to Cristiano Ronaldo, who cushioned the ball back to Van de Beek with his head for the midfielder to score. Manchester United were seemingly back in it with the visitors pumped and ready to pull off a miraculous comeback.Premier League@premierleagueFULL-TIME Watford 4-1 Man UtdLate goals from Emmanuel Dennis and Joao Pedro cap off a remarkable afternoon for @WatfordFC#WATMUN10:29 AM · Nov 20, 20212510441FULL-TIME Watford 4-1 Man UtdLate goals from Emmanuel Dennis and Joao Pedro cap off a remarkable afternoon for @WatfordFC#WATMUN https://t.co/6TDgbMAOe3Cristiano Ronaldo was then denied from close-range by Ben Foster as Watford held on to their lead. Hopes of a Manchester United comeback were extinguished when Harry Maguire received the marching orders in the 69th minute. The Englishman, who was already on a yellow card, committed a reckless challenge on Tom Cleverley and the referee did not think twice before sending him off.Cristiano Ronaldo fired a number of attempts off target to add to Manchester United frustrationMeanwhile, Cristiano Ronaldo produced a few shots off target at the other end as frustration mounted for Manchester United. Joao Pedro and Dennis landed the final blows in second-half stoppage time to complete a famous win for Watford.In the wake of another chastening experience for Manchester United, Twitter went into a frenzy. Here are some of the best reactions as Cristiano Ronaldo and company endured another forgettable evening:FootballJOE@FootballJOEYou know you're down bad when *Watford* fans are singing about *your* manager getting sacked9:24 AM · Nov 20, 202148053You know you're down bad when *Watford* fans are singing about *your* manager getting sackedJan Aage Fjørtoft 🏳️‍🌈 🇳🇴@JanAageFjortoftMan UTD been shocking 1st half! Watford playing them off the park. And we know consequences….You can’t sack a whole team9:20 AM · Nov 20, 20211667113Man UTD been shocking 1st half! Watford playing them off the park. And we know consequences….You can’t sack a whole teamNooruddean@BeardedGeniusManchester United9:26 AM · Nov 20, 202137636Manchester United https://t.co/WmGUkncw65B/R Football@brfootballOne win in last six Premier League games.Down 2-0 to Watford at half-time. 😬9:19 AM · Nov 20, 2021103061285One win in last six Premier League games.Down 2-0 to Watford at half-time. 😬 https://t.co/CnRAPGF6ZqAdam Crafton@AdamCrafton_Solskjaer would have been sacked three times by Watford during this half alone.9:18 AM · Nov 20, 20214430815Solskjaer would have been sacked three times by Watford during this half alone.Drax@LaMasiaStanOle when Manchester United equalised and then sees it was a goal by Donny van de Beek#WATMUN9:50 AM · Nov 20, 20215110Ole when Manchester United equalised and then sees it was a goal by Donny van de Beek#WATMUN https://t.co/2EpOW79hTKSean Cavigan@seancaviganIf I see a sorry Instagram post from Harry Maguire I’m gonna fucking shoot myself10:22 AM · Nov 20, 2021If I see a sorry Instagram post from Harry Maguire I’m gonna fucking shoot myselfKabir Moni Patel@KabeerMoniIf you hate ole, we are automatically friends. 😂😂#OleOut please @ManUtd#WATMUN10:23 AM · Nov 20, 2021If you hate ole, we are automatically friends. 😂😂#OleOut please @ManUtd#WATMUNLEOGOAT10@leo7messixRt if you agree #WATMUN #OleOut10:23 AM · Nov 20, 2021Rt if you agree #WATMUN #OleOut https://t.co/NJucVvbSWZSachin Suryavanshi 🌞@imsuryavanshi3#WATMUNOle the 🤡10:23 AM · Nov 20, 2021#WATMUNOle the 🤡 https://t.co/FXHP8gX5rIReshmika@reshmufcSurely Ole’s time is up now...10:21 AM · Nov 20, 2021444Surely Ole’s time is up now...FOX Soccer@FOXSoccerMan Utd fans rn after losing to Watford 😅10:25 AM · Nov 20, 20218616Man Utd fans rn after losing to Watford 😅 https://t.co/DktJoarn1OB/R Football@brfootballFT: Watford 4-1 Manchester UnitedOle's still at the wheel 🙃10:25 AM · Nov 20, 20211507351FT: Watford 4-1 Manchester UnitedOle's still at the wheel 🙃 https://t.co/T1INcTlKCmStatman Dave@StatmanDaveManchester United now have a negative goal difference in the Premier League this season.10:23 AM · Nov 20, 202149987Manchester United now have a negative goal difference in the Premier League this season. https://t.co/nTWNzXpRUIDEE📸@official_dee_elMaguire Critics still not silenced I’m hearing 😂10:26 AM · Nov 20, 2021Maguire Critics still not silenced I’m hearing 😂 https://t.co/d3eGOs4e6fAlfie@OhAlfff@ManUtd “But at least Van de beek scored eh lads”10:26 AM · Nov 20, 2021@ManUtd “But at least Van de beek scored eh lads” https://t.co/RNtfddyNwEblankspace@shomurodowBANTER CLUB #WATMUN10:26 AM · Nov 20, 20211BANTER CLUB #WATMUN https://t.co/S5m6x73LO5derekholohan@derekholohanShocking stuff #OleOut #mufc10:26 AM · Nov 20, 20211Shocking stuff #OleOut #mufc https://t.co/w6Y9SM7rgQalfie 🇮🇹@28NdombeIeBen Foster has more G/A than Sancho looool10:26 AM · Nov 20, 2021251Ben Foster has more G/A than Sancho loooolSquawka Football@SquawkaPremier League games lost to Watford as Manchester United manager:2 - Ole Gunnar Solskjaer1 - Jose Mourinho 0 - Sir Alex Ferguson Ole is stung again by the Hornets. 🐝10:26 AM · Nov 20, 202118145Premier League games lost to Watford as Manchester United manager:2 - Ole Gunnar Solskjaer1 - Jose Mourinho 0 - Sir Alex Ferguson Ole is stung again by the Hornets. 🐝 https://t.co/XHBVhVH3ENTwtManUtd@twtmanutdProper, hurt animal you know 🤢 twitter.com/utddistrict/st…UtdDistrict@UtdDistrict🗣 Solskjær: “We have to come out against Watford like a proper, hurt animal.”10:21 AM · Nov 20, 2021147🗣 Solskjær: “We have to come out against Watford like a proper, hurt animal.”Proper, hurt animal you know 🤢 twitter.com/utddistrict/st…Byron🇹🇿@byron_g17Maguire getting sent off and not being available for Chelsea #WATMUN10:09 AM · Nov 20, 20213Maguire getting sent off and not being available for Chelsea #WATMUN https://t.co/NylRVOMdL4⚽️442oons⚽️@442oonsOle's at the wheel #WATMUN10:08 AM · Nov 20, 202122017Ole's at the wheel #WATMUN https://t.co/t8bg14W0Jwprevail 😂🤷🏾‍♀️😊💨@FantastizeeyFootball is difficult for wan-bissaka #WATMUN9:51 AM · Nov 20, 20213Football is difficult for wan-bissaka #WATMUN https://t.co/PglhVIdWLz🌊@summersexual_Currently feeling bad for all the Ronaldo fans that followed him to United 😭10:30 AM · Nov 20, 2021Currently feeling bad for all the Ronaldo fans that followed him to United 😭𝗘𝗦𝗠𝗔🕊️@EsmaDangoteCristiano Ronaldo is the worst thing that ever happened to Manchester United.10:29 AM · Nov 20, 20211Cristiano Ronaldo is the worst thing that ever happened to Manchester United.not Remy Shoots@KupfuwaJeremyYou’ll give your boyfriend as many chances as Ronaldo got from Manchester United and he’ll still flip for you..... that’s just life.10:29 AM · Nov 20, 2021You’ll give your boyfriend as many chances as Ronaldo got from Manchester United and he’ll still flip for you..... that’s just life.DON@OpresiiManchester United went to Watford 4-1 mission but Cristiano Ronaldo didn’t show up.10:29 AM · Nov 20, 20215315Manchester United went to Watford 4-1 mission but Cristiano Ronaldo didn’t show up.talkSPORT@talkSPORTOle Gunnar Solskjaer putting his hands up to the #MUFC away end…Is this him waving goodbye? 👀10:32 AM · Nov 20, 2021304Ole Gunnar Solskjaer putting his hands up to the #MUFC away end…Is this him waving goodbye? 👀 https://t.co/0yXD0Q2qwvHarlem@s1orderRonaldo doing his complimentary goal contribution regardless of United's run of terrible results is killing me10:29 AM · Nov 20, 20214Ronaldo doing his complimentary goal contribution regardless of United's run of terrible results is killing me