Ajax produced arguably the biggest upset in the past decade of the Champions League as they humiliated the defending champions Real Madrid, knocking the holders out of the competition in the round of 16.Many felt Ajax deserved a victory in the first leg at Amsterdam, but naivety and poor finishing cost the Dutch side who ended up on the wrong side of a 2-1 result. However, they did little wrong in the second leg at the Bernabeu as they crushed the hosts by four goals to one.Hakim Ziyech got things rolling for the visitors as early as the seventh minute before David Neres added a second following a scintillating display of footwork from Dusan Tadic ten minutes later.Tadic, who had assisted both previous goals, then got one for himself in extremely controversial circumstances, with VAR likely to come under scrutiny in the aftermath of the game. The ball seemed to have rolled out of play in the build-up to the goal, but the benefit of doubt went with the visitors whose fans could hardly believe what they were witnessing.While substitute Marco Asensio looked to have got one back for the hosts, a stunning free-kick just minutes later by Lasse Schone all but sealed progression for Ajax.A red card for Nacho late on made matters just that much worse for Madrid. The defeat adds to the uncertainty surrounding Madrid manager Santiago Solari's future, and he could be shown the door sooner rather than later. For Real Madrid, on the other hand, it looks like an unprecedented trophyless season, with the club out of the Copa del Rey and 12 points off league leaders and arch-rivals Barcelona in LaLiga.Also see : La Liga Transfer News, EPL Transfer News, Gold Cup StandingsTwitter had a field day reacting to Real Madrid's shocking exit. Here are some of the best tweets.Real Madrid 😂😭 pic.twitter.com/e8SY0lP3MZ— Troll Football (@TrollFootball) March 5, 2019Ajax singing “Always look on the bright side of life” in the Bernabeu. 😂👏 #RMAAJA pic.twitter.com/SurKfzbh0u— Sports News (@FIFAWCGoals) March 5, 2019Real Madrid with Ronaldo vs Real Madrid without Ronaldo😂😂#RMAAJA pic.twitter.com/GkdyINd1UE— Patrick 🇰🇪 (@PatricPatricks) March 5, 2019Hit map of Real Madrid vs Ajax #RMAAJA pic.twitter.com/KOYKakeaOh— coolestguy (@coolestguy2891) March 5, 2019Real Madrid with Ronaldo versus without Ronaldo#RMAAJA pic.twitter.com/kh74vZcVrl— Whale (@YorubaBoyMedia) March 5, 2019#RMAAJAUnbelievable skills... R. Madrid can't handle Ajax 🔥 pic.twitter.com/3hHe1sX1JW— Iris Chris (@iamirischris) March 5, 2019No caption needed.😏 #UCL pic.twitter.com/M5OkTS43iC— Indy Football (@IndyFootball) March 5, 2019Watching us go out of the #UCL like... #RealMadridAjax pic.twitter.com/uIqFlxKCPW— Michael Cormack (@MichaelCormack7) March 5, 2019We need a VAR for the VAR.#RealMadridAjax #UCL pic.twitter.com/7s916FwjPE— Kevin (@Kevin04764411) March 5, 2019FRENKIE DE JONG Remember the name! Totally bossing REAL MADRID at Santiago BernaLeo.#RealAjax #Ajax #RealMadrid #UCL pic.twitter.com/9HePtsV3zy— Aian Xaharia (@Aianation23) March 5, 2019Yo, @GarethBale11, look what you guys did!#RealMadridAjax pic.twitter.com/6gSwV07fNO— fuboTV (@fuboTV) March 5, 2019#Ramos you're a genius! #RealMadridAjax pic.twitter.com/2ZfnPWlpyr— TalkSportClub (@TalkSportClub1) March 5, 2019Cristiano Ronaldo at home watching Real Madrid vs Ajax!#RMAAJA #UCL pic.twitter.com/Wd7KKk70Th— Lavish Mall (@LavishingLavish) March 5, 2019The @Benzema slip 😂😂#RMAAJA #UCL pic.twitter.com/wmksOk6H2O— शराबी ! (@NeatPeg) March 5, 2019With Ronaldo:Madrid win 4-1Without Ronaldo:Madrid lose 4-1 pic.twitter.com/xOansQ4zPl— FootballFunnys (@FootballFunnnys) March 5, 2019Ajax's total wage budget for the 1st, 2nd and youth team is same as what Gareth Bale earns at Real Madrid. pic.twitter.com/aAlrD3ilQT— Nitwik Football (@NitwikFootball) March 5, 2019Don't worry Madrid fans, at least you are still in Copa Del R... Fighting for LaLig... Eh, how's the youth team doing?— Football Buzz (@FootballBuzzHQ) March 5, 2019Thibaut Courtois trying to save that free kick. pic.twitter.com/M0I3X4YUBh— Sripad (@falsewinger) March 5, 2019