Velez Sarsfield will welcome Barcelona SC to Estadio Jose Amalfitani on Wednesday for the first leg of their Copa Libertadores round-of-16 tie.The home side secured their spot at this stage of the tournament by virtue of their second-place finish in Group G. The Buenos Aires outfit finished with 10 points, two points behind table-toppers Flamengo.Barcelona SC finished top of Group C, three points ahead of Argentine heavyweights Boca Juniors.Velez Sarsfield have not been in action since playing a goalless draw with Flamengo in their final group stage game at the end of May. View this post on Instagram A post shared by Vélez Sarsfield (@velez)Barcelona SC were held to a 1-1 draw by Emelec on home turf on Saturday. Carlos Garces scored a second-half equalizer for the hosts after Sebastian Rodrigues had put Emelec ahead in the first half.Also See: Fabrizio Romano's Transfer Roundup: Manchester United pushing for 2 more transfers, Barcelona's plans for Lionel Messi and moreVelez Sarsfield vs Barcelona SC Head-to-HeadThis will be the first meeting between the sides. The visitors have two wins from their last five games in all competitions.The home side have not been in action for over a month. Their penalty shootout defeat to Racing Club saw them eliminated from the 2021 Copa de la Liga Profesional.Velez Sarsfield form guide: D-W-L-W-WBarcelona SC form guide: D-L-W-L-WVelez Sarsfield vs Barcelona SC Team NewsVelez Sarsfield Agustin Mulet has been ruled out with heart-related issues. Francisco Ortega is currently with the Argentina Under-23 team for the Olympics but would have been suspended due to the red card he received against Flamengo.Heart issue: Agustin MuletSuspension/International Duty: Francisco Ortega View this post on Instagram A post shared by BarcelonaSC (@barcelonasc)Barcelona SCGabriel Marques, Dario Aimar and Pedro Velasco are all still sidelined with long-term injuries.Injuries: Gabriel Marques, Dario Aimar, Pedro VelascoSuspension: NoneVelez Sarsfield vs Barcelona SC Predicted XI Velez Sarsfield Predicted XI (4-2-3-1): Lucas Hoyos (GK); Miguel Brizuela, Lautaro Giannetti, Matias de los Santos, Tomas Guidara; Santiago Caseres, Federico Mancuello; Lucas Janson, Thiago Almada, Ricardo Centurion; Juan-Martin LuceroBarcelona SC Predicted XI (4-4-2): Javier Burrai (GK); Leonel Quinones, William Riveros, Fernando Leon, Byron Castillo; Carcelen Carabali, Emmanuel Martinez, Nixon Molina, Michael Hoyos; Damian Diaz, Carlos AcostaVelez Sarsfield vs Barcelona SC Velez Sarsfield have not been in action for over six weeks and this could have an adverse effect when playing against Barcelona SC.The two sides have compact defenses, which could see both attacks struggle to create chances. But Velez Sarsfield have enough quality to narrowly nick a home win.Prediction: Velez Sarsfield 1-0 Barcelona SCAlso See: Alashkert vs Connah's Quay prediction, preview, team news and more | UEFA Champions League qualifiers 2021-22