The home side come into the clash on the back of a 3-1 defeat away to Oman last month. Tien Linh Nguyen put Vietnam ahead in the 39th minute but a second-half fightback saw the home side secure a comeback victory.
Japan returned to winning ways with a hard-fought 2-1 victory over Australia on home turf. Aziz Behich's second-half own goal helped the Blue Samurai secure maximum points.
That win saw Japan move to six points, which is only good enough for fourth place in Group B. Vietnam sit in bottom place and are yet to register their first points after four matches.
Vietnam vs Japan Head-to-Head
This will be only the fifth meeting between the two sides and Japan have a 100% record with four wins to their name.
Their most recent clash came in the quarterfinals of the 2019 Asian Cup. Ritsu Doan's second-half penalty helped Japan secure progress with a 1-0 victory en-route to their second-place finish.
Vietnam are currently on a five-game losing streak. Japan's indifferent start to the qualifiers has left them playing catch-up in the race to secure qualification for Qatar 2022.
Vietnam form guide: L-L-L-L-L
Japan form guide: W-L-W-L-W
Vietnam vs Japan Team News
Coach Park Hang-seo called up 34 players to dispute the qualifiers against Japan and Saudi Arabia.
Experienced players like Yuto Nagatomo, Eiji Kawashima and team captain Maya Yoshida headline the squad of 28 players called up for the games against Vietnam and Oman.
Vietnam vs Japan Predicted XI
Vietnam Predicted XI (5-4-1): Bui Tan Trong (GK); Que Ngoc Hai, Bui Tieng Dung, Nguyen Thanh Chung, Nguyen Phong Hong Duy, Vu Van Thanh; Nguyen Hoang Duc, Phan Van Duc, Nguyen Tuan Anh, Nguyen Quang Hai; Nguyen Tien Linh
Japan Predicted XI (4-2-3-1): Shuichi Gonda (GK); Yuto Nagatomo, Maya Yoshida, Hiroki Sakai, Takehiro Tomiyasu; Wataru Endo, Gaku Shibasaki; Takuma Asano, Daichi Kamada, Takumi Minamino; Yuya Osako
Vietnam vs Japan Prediction
Despite their recent inconsistent form, Japan are still favorites to emerge triumphant against a poor Vietnamese side. The visitors need maximum points to keep pace in the race for automatic qualification and are likely to go all out for victory.
Hajime Moriyasu's side have too much firepower for their hosts and we are backing them to emerge triumphant in a comfortable victory.
Prediction: Vietnam 0-3 Japan