Second in Group G with seven points, the Vites are competing with Tottenham Hotspur for a place in the preliminary round.
A win is a must unless Spurs lose to Rennes in the other game, because in that case, a draw would be enough to go through.
However, if both sides win, then the group runner-up will be decided on goal difference.
Meanwhile, Mura are bottom with only three points and already eliminated from the race.
However, the side caused their biggest upset in history with a 2-1 defeat of Antonio Conte's side on the last matchday.
Vitesse vs Mura Head-To-Head
The September reverse between the sides was their first-ever clash in Europe.
Vitesse came away with a comfortable 2-0 victory in Maribor courtesy of goals from Sondre Tronstad and Danilho Doekhi.
Vitesse Form Guide (all competitions): W-L-D-D-W
Mura Form Guide (all competitions): L-D-W-W-W
Vitesse vs Mura Team News
Besides long-term absentee Daan Reiziger, who's been out with an ankle injury since August and isn't expected to return until January, the Dutch side have a clean bill of health.
Also boosting manager Thomas Letsch's options are the return of Dokehi and Markus Schubert, both of whom missed their 3-3 draw with Rennes through suspension.
Injured: Daan Reiziger
Ziga Skoflek has been out since October and will remain sidelined for this clash.
The side's top-scorer Amadej Marosa, who missed their weekend tie, will return to the starting XI and lead the line once again. Mitja Lotric is another key player pushing to start.
Injured: Ziga Skoflek
Vitesse vs Mura Predicted XI
Vitesse (3-4-1-2): Markus Schubert; Danilho Doekhi, Jacob Rasmussen, Riechedly Bazoer; Eli Dasa, Sondre Tronstad, Daan Huisman, Maximilian Wittek; Yann Gboho; Thomas Buitink, Loïs Openda.
Mura (5-4-1): Matko Obradovic; Marin Karamarko, Zan Karnicnik, Jan Gorenc, Klemen Sturm, Klemen Pucko; Nik Lorbek, Alen Kozar, Tomi Horvat, Ziga Kous; Amadej Marosa.
Vitesse vs Mura Prediction
Vitesse have an impressive squad and have given the top dogs in the group a real run for their money.
Mura will be looking to cause another upset following the Tottenham defeat but lightening won't likely strike twice.
A comfortable victory for the home side is on the cards.
Prediction: Vitesse 2-0 Mura