Best NFL Prop Bets for Today: 49ers vs. Cardinals - November 21 - NFL Week 11 | 2022 NFL Football Season

Arizona Cardinals v Los Angeles Rams
Arizona Cardinals v Los Angeles Rams

Plenty of player props will be available to wrap up the NFL Week 11 slate between the San Francisco 49ers and the Arizona Cardinals in Mexico City on Monday Night Football.

The 49ers have gone all in on this year and are trying to overtake the Seahawks in the NFC West while the Cardinals are trying to get back to .500 ball. Below are the best prop bets you can make and they are provided by DraftKings Sportsbook.


San Francisco 49ers vs. Arizona Cardinals Match Details

Fixture: San Francisco 49ers @ Arizona Cardinals

Date & Time: Monday, November 21, 8:15 p.m. EDT

Venue: Estadio Azteca, Mexico City, Mexico


NFL Player Prop #1: James Conner Over 49.5 Rushing Yards (-115)

It sounds like Kyler Murray is going to miss his second consecutive game with a hamstring injury and that means the running game is going to have to step up and control the pace of the game. Looking at last week's game against the Los Angeles Rams, James Conner finished with 69 rushing yards on 21 carries and should be right around there as he will be an important contributor to this Arizona offense.


NFL Player Prop #2: Deebo Samuel Over 52.5 Receiving Yards (-110)

Imagine the line for a number one wide receiver being this low for any other team but the San Francisco 49ers. Deebo Samuel has played pretty well and finished with 58 and 63 receiving yards in his two games last season against the Cardinals a year ago.

This Arizona defense is going to struggle as San Francisco has a bunch of skilled players that can dominate throughout the game. Samuel is averaging eight targets in his last four games so they are making sure he gets a bunch of solid looks this year.


NFL Player Prop #3: Jimmy Garoppolo Under 1.5 Touchdown Passes (-105)

Jimmy Garoppolo is not a great quarterback to the point where he started the season as the backup quarterback for the team. However, he is not going to turn the ball over too much and will do well in this matchup.

However, with the likes of Christian McCaffrey and Deebo Samuel being able to dominate on the ground, expect them to get the ball and run into the end zone. Jimmy G only has 11 passing touchdowns this season so go with the under here.

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