The action continues on Day 4 of the Sud de France Open 2020 at Montpellier after a few surprising results opened up the event, which is part of the ATP World Tour 250 series.
Gasquet, who returned to action after missing the Australian Open through injury, surprised spectators who expected the 33-year-old to be more circumspect in his comeback match.
He will now take on Lopez in the last-16, who delighted his fans with a win over Auckland Open champion Humbert.
David Goffin will also be in action on Day 4. Goffin had a decent stint at Melbourne, where he reached the third round before losing to Andrey Rublev in a tight four-setter. He has since moved up one place in the ATP rankings into the top ten after last week's events.
Goffin is seeded second at Montpellier and consequently received a bye to the second round, where he will face Alexander Bublik of Kazakhstan.
The Russian-born 22-year-old fought his way past Henri Laaksonen in three sets but is expected to find it hard matching a player of Goffin's calibre.
Here is the ATP Open Sud de France Schedule for Day 4:
Mikael Ymer vs Filip Krajinovic - Approx 16:30 (IST)
Prediction: Mikael Ymer to win in three sets
Alexander Bublik vs David Goffin - Approx 18:30 (IST)
Prediction: David Goffin to win in two sets
Richard Gasquet vs Feliciano Lopez - Approx 19:50 (IST)
Prediction: Richard Gasquet to win in two sets
Emil Ruusuvuori vs Norbert Gombos - Approx 21:30 (IST)
Prediction: Emil Ruusuvuori to win in three sets
Felix Auger Aliassime vs Pierre-Hugues Herbert - Approx 23:30 (IST)
Prediction: Felix Auger Aliassime to win in two sets
Gael Monfils vs Adrian Mannarino - Approx 00:50 (IST) on Friday
Prediction: Gael Monfils to win in three sets