Who plays Estrogen in Big Mouth season 8? Everything to know about the actor behind the role

Big Mouth season 8 marks the final season of the American adult animated coming-of-age sitcom created by Nick Kroll and Andrew Goldberg. With this being the last season, the comedy goes all-out, putting its adolescent characters through the wringer with new characters who feel all too familiar to anyone who has gone through puberty and teenage years.

Episode 3 of Big Mouth season 8 focuses on puberty for Nick and his friends. They tease each other about the physical changes and experiences they have at this stage, like Nick's growth spurt and other things, while Andrew is portrayed at the peak of puberty, even worrying about possibly going bald.

To help them understand all the stages of puberty, Ms. Dunn takes everyone on a field trip inside the teenage body. There, they meet everyone involved during such a transformative stage in life, including Estrogen. Skyla I'Lece voices Estrogen, who teaches Nick and his friends about the menstrual cycle, in Big Mouth season 8.

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Who is Estrogen in Big Mouth season 8?

In Big Mouth season 8 episode 3, titled Why Do We Go Through Puberty?, Nick and his classmates journey inside the body of a female adolescent. They enter the brain and meet the neurons, then move through the pituitary gland, the kidneys, and the ovaries. In one of the ovaries, Estrogen, voiced by Skyla I'Lece, makes a whole production in front of the class.

The blonde, purple-faced Estrogen steps onto a shell-shaped stage to introduce herself as "the hormone that makes it all happen" before belting out The Cycle of My Life. She sings about the menstrual cycle, explaining how she can be a girl's worst enemy and then her best friend.

Jessie, who has been extra crabby and emotional throughout the field trip, relates to Estrogen's song and realizes that she's in her luteal phase and experiencing premenstrual syndrome.

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All about Skyla I'Lece, who voiced Estrogen in Big Mouth season 8

Skyla I'Lece showcases her talent in both acting and singing as the voice of Estrogen in Big Mouth season 8. She's been acting since she was young, starting in theater before making a name for herself in television. Per her IMDb page, her TV debut came in 2017 with a cameo role as a 9-year-old girl in AMC's TURN: Washington's Spies.

Her next TV role came in the showbiz drama P-Valley on Starz, where she joined the cast in a recurring role during its first and second seasons. However, her breakout role was in Disney's adaptation of the basketball coming-of-age drama The Crossover. She starred in the LeBron James-produced series as Alexis, the childhood friend of the teen brothers at the center of the story.

Before her voice-acting stint in Big Mouth season 8, she also voiced Holly Honeywell in Apple TV+'s computer animation Be@rbrick.

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She started in musical theater

In her exclusive feature for Just Jared Jr., published on April 5, 2023, Skyla I'Lece revealed that before becoming a TV actress, she started acting onstage. She was cast in several musical theater productions, including The Little Mermaid, Mary Poppins, Annie, and The Secret Garden.

She shared that her role as Mary Lennox in Tim Sieb's The Secret Garden earned her a nomination as "Best Actress in a Musical" from Broadway World. She was also nominated as "Best Featured Actress in a Musical" for playing Baby June in Eric Woodall's Gypsy.

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She was a former pageant queen

Skyla I'Lece also told Just Jared Jr. that she was crowned National All American Miss Princess pageant Queen when she was seven years old. She explained that after being named runner-up in North Carolina, she was able to compete at the national level in California, where she was crowned.

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All eight seasons of Big Mouth are now streaming on Netflix.