Marlins vs. Cardinals: Game 3 prediction, lineup, odds, injuries, and picks

Wednesday will be the final time the Miami Marlins and the St. Louis Cardinals meet this season.

The Cardinals have a 3-2 lead in the regular season series, having taken the first two games of the current one. In no way will it be a dead rubber to them if they are to stay in the NL Wild Card hunt.

The Cardinals are 63-64 and 5.0 games outside the Wild Card spots cut-off. A five-game losing streak heading into the series has jolted their chances. The Marlins, 59-67, meanwhile, are struggling with form, too, with two wins in their last 11.

Marlins vs. Cardinals Game 3: Betting Odds & Weather

Time: 6:40 p.m. ET at loanDepot Park

Money Line: Marlins -125, Cardinals +105

Total Runs: Over/Under is 8.5 runs

Weather: In domed stadium, not applicable

Marlins vs. Cardinals Game 3: Injuries & Lineups

Injuries

Marlins

Graham Pauley: 10 Day IL (Oblique),
Kyle Stowers: 10 Day IL (Oblique),
Connor Norby: 10 Day IL (Wrist),
Anthony Bender: 15 Day IL (Tibia),
Jesus Tinoco: 60 Day IL (Forearm),
Braxton Garrett: 60 Day IL (Elbow),
Andrew Nardi: 60 Day IL (Back),
Griffin Conine: 60 Day IL (Arm),
Max Meyer: 60 Day IL (Hip),
Ryan Weathers: 60 Day IL (Lat)

Cardinals

Nolan Arenado: 10 Day IL (Shoulder),
Brendan Donovan: 10 Day IL (Groin),
Victor Scott II: 10 Day IL (Ankle),
John King: 15 Day IL (Oblique),
Zack Thompson: 60 Day IL (Lat)

Expected Lineups

Marlins

2B X. Edwards S
CF Jakob Marsee L
C A. Ramirez R
SS Otto Lopez R
DH Liam Hicks L
LF H. Hernandez R
1B T. Johnston L
RF Dane Myers R
3B J. Sanoja R

Cardinals

RF L. Nootbaar L
DH Ivan Herrera R
LF A. Burleson L
1B W. Contreras R
SS Masyn Winn R
3B Nolan Gorman L
2B T. Saggese R
C Pedro Pages R
CF N. Church L

Marlins vs. Cardinals Game 3: Expert picks and prediction

Andre Pallante (6-10, 5.04 ERA, 1.38 WHIP) of the Cardinals faces off against Sandy Alcantara (6-11, 6.31 ERA, 1.41 WHIP) of the Marlins. Both records represent the collective pitching of both teams: the Cardinals' 4.23 ERA is 20th in the MLB, while the Marlins' 4.55 ERA is 24th.

However, Alcantara has sprung surprise good starts, having earned one or less runs in three of his last five starts. Both teams, though, have the 11th-best collective batting average at .250, with the duos of Xavier Edwards and Kyle Stowers for Miami and Alec Burleson and Willson Contreras for St. Louis expected to support their starters.

Prediction: Marlins 6, Cardinals 5

Picks: Marlins ML (-125), Over 8.5 runs

About the author

Nikhil Parshy is a baseball and ice hockey journalist at Sportskeeda, and after starting out as a cricket reporter, he has been an analyst with SK since November 2022. His interest in the sports were piqued a few years back after watching highlights on YouTube and he has followed the game ever since.

The Chicago Cubs breaking the 108-year curse in 2016 to lift the World Series remains Nikhil's favorite baseball moment. Two-way phenom Shohei Ohtani has been his favorite player ever since he started following the game, while the LA Dodgers are his favorite team.

As a writer, Nikhil maintains a strong attention to detail and rigorously cross-checks information. He seeks to strike a balance in his writing such that the regular reader gains an insight into player profiles, while also keeping in mind that the non-regular reader is not put off by jargon and shallow analysis.

Nikhil is an avid public speaker, and when not writing about baseball, he regularly participates in debates and quizzes.

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Edited by Bhargav

Marlins vs. Cardinals: Game 3 prediction, lineup, odds, injuries, and picks - August 20, 2025

Marlins vs. Cardinals Game 3: Betting Odds & Weather

Marlins vs. Cardinals Game 3: Injuries & Lineups

Injuries

Marlins

Cardinals

Expected Lineups

Marlins

Cardinals

Marlins vs. Cardinals Game 3: Expert picks and prediction