Orioles vs. Pirates: Game 1 prediction, lineup, odds, injuries, and picks

The Baltimore Orioles are set to continue their home stretch for a three-game series against the Pittsburgh Pirates. Both teams are last in their respective divisions, out of contention for the playoffs, and so just looking to end their regular season on a high.

The Orioles (66-77) are on a roll, winning five of their last sixgames. It has been an incredible turnaround for Maryland's team, which had dropped nine of its previous 11 games.

The Milwaukee Brewers swept the Pirates (64-80) over the weekend. Before that series, they had compiled five wins against the Los Angeles Dodgers and Boston Red Sox.

Orioles vs. Pirates Game 1: Betting Odds and Weather

Time: 6:35 p.m. ET at Orioles Park at Camden Yards

Money Line: Orioles -158, Pirates +132

Total Runs: Over/Under is 8.5 runs

Weather: Mostly Sunny, 74 degrees F, 0% precipitation, Wind 8 mph R-L

Orioles vs. Pirates Game 1: Injuries and Lineups

Injuries

Orioles

Jordan Westburg: 10 Day IL (Ankle),
Tyler O’Neill: 10 Day IL (Wrist),
Adley Rutschman: 10 Day IL (Oblique),
Colin Selby: 15 Day IL (Hamstring),
Felix Bautista: 60 Day IL (Shoulder),
Scott Blewett: 60 Day IL (Elbow),
Zach Eflin: 60 Day IL (Back),
Grayson Rodriguez: 60 Day IL (Elbow),
Brandon Young: 60 Day IL (Hamstring),
Gary Sánchez: 60 Day IL (Knee),
Samuel Basallo: day-to-day (Hand),
Dean Kremer: day-to-day (Forearm)

Pirates

Jack Suwinski: 10 Day IL (Groin),
Ronny Simon: 10 Day IL (Shoulder),
Justin Lawrence: 60 Day IL (Elbow),
Endy Rodriguez: 60 Day IL (Elbow),
Jared Jones: 60 Day IL (Elbow),
Enmanuel Valdez: 60 Day IL (Shoulder)

Expected Lineups

Orioles

2B J. Holliday L
RF J. Jackson R
SS G. Henderson L
DH R. Mountcastle R
CF C. Cowser L
C S. Basallo L
3B E. Rivera R
LF D. Beavers L
1B Coby Mayo R

Pirates

SS Jared Triolo R
1B S. Horwitz L
RF B. Reynolds S
LF Tommy Pham R
DH A. McCutchen R
2B N. Gonzales R
CF Oneil Cruz L
C Henry Davis R
3B Cam Devanney R

Orioles vs. Pirates Game 1: Expert Picks and Prediction

Pittsburgh's Mike Burrows (2-4, 4.08 ERA) faces Baltimore's Kyle Bradish (0-1, 3.60 ERA) in the starting pitcher battle. Burrows will make his return to the starting rotation after throwing in a bulk relief role in the previous two games. He has 2 earned runs in his last 14.0 innings. Bradish makes his third start of the season.

The Pirates have a better collective pitching staff (3.91 ERA), but the Orioles' lineup has scored 98 more runs than theirs all season. Moreover, the Pirates are known to be better hitters at home, leaving the O's at an advantage. Oneil Cruz and Bryan Reynolds remain their most important at-bats, while Baltimore will rely on Jackson Holliday and Gunnar Henderson.

Prediction: Orioles 5, Pirates 4

Picks: Orioles ML (-158), Under 8.5 runs

About the author

Nikhil Parshy is a baseball and ice hockey journalist at Sportskeeda, and after starting out as a cricket reporter, he has been an analyst with SK since November 2022. His interest in the sports were piqued a few years back after watching highlights on YouTube and he has followed the game ever since.

The Chicago Cubs breaking the 108-year curse in 2016 to lift the World Series remains Nikhil's favorite baseball moment. Two-way phenom Shohei Ohtani has been his favorite player ever since he started following the game, while the LA Dodgers are his favorite team.

As a writer, Nikhil maintains a strong attention to detail and rigorously cross-checks information. He seeks to strike a balance in his writing such that the regular reader gains an insight into player profiles, while also keeping in mind that the non-regular reader is not put off by jargon and shallow analysis.

Nikhil is an avid public speaker, and when not writing about baseball, he regularly participates in debates and quizzes.

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Edited by R. Nikhil Parshy

Orioles vs. Pirates: Game 1 prediction, lineup, odds, injuries, and picks - September 9, 2025

Orioles vs. Pirates Game 1: Betting Odds and Weather

Orioles vs. Pirates Game 1: Injuries and Lineups

Injuries

Orioles

Pirates

Expected Lineups

Orioles

Pirates

Orioles vs. Pirates Game 1: Expert Picks and Prediction