Padres vs Brewers: Game 2 prediction, odds, injuries and picks - June 7, 2025

San Diego Padres v Milwaukee Brewers - Source: Getty
San Diego Padres v Milwaukee Brewers - Source: Getty

The Padres look to claim the series in Game 2 of their three-game set against the Brewers in Milwaukee. San Diego came away with a comfortable 2-0 victory in the opening matchup that featured a scarcity of offense from the home squad.

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Luis Arraez's RBI single and Manny Machado's solo shot were the only runs scored in the ball game as the Friars' pitching crew limited the Brewers' offense to four base hits. Wandy Peralta was awarded the victory while Robert Suarez tallied a major league-leading 20th save of the season.

Padres vs. Brewers recent form and records

The Friars are still hot on the heels of the Dodgers in the National League West standings and are just one game behind the champions. They sport a 36-26 record and a 16-16 tally away from home.

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Milwaukee, meanwhile, has been surging as of late. Despite the loss in the opening game, they have won eight of their last 10 games. The Brewers possess a 34-30 record that is good for third in the NL Central with an 18-11 record at home.

Padres vs. Brewers odds

Money Line: SD (+102), MIL (-112)

Run Spread: SD -1.5 (+156), MIL +1.5 (-197)

Total Runs: O 8.5 (-105), U 8.5 (-114)

Padres vs. Brewers injuries

SD injury report

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  • Ethan Salas (C): Day-to-day (back)
  • Logan Gillespie (RP): 15-day IL (oblique)
  • Jhony Brito (RP): 60-day IL (elbow, flexor tendon)
  • Yu Darvish (SP): 15-day IL (elbow)
  • Bryan Hoeing (RP): 60-day IL (shoulder)
  • Michael King (SP): 15-day IL (shoulder)
  • Jason Heyward (LF): 10-day IL (oblique)
  • Joe Musgrove (SP): 60-day IL (elbow)
  • Mason McCoy (2B): 10-day IL (finger)

MIL injury report

  • Brandon Woodruff (SP): 15-day IL (elbow)
  • Ramon Rodriguez (C): Full season IL (undisclosed)
  • Robert Gasser (SP): 60-day IL (elbow)
  • Connor Thomas (RP): 60-day IL (elbow)
  • Blake Perkins (CF): 60-day IL (shin)
  • Nestor Cortes Jr. (SP): 60-day IL (elbow)
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Padres vs. Brewers projected lineup

SD projected lineup

  • Fernando Tatis Jr. (RF)
  • Luis Arraez (1B)
  • Manny Machado (3B)
  • Jackson Merrill (CF)
  • Xander Bogaerts (SS)
  • Gavin Sheets (LF)
  • Luis Campusano (DH)
  • Jake Cronenworth (2B)
  • Martin Maldonado (C)
  • Stephen Kolek (SP, 3-1 | 3.47 ERA | 27 K)

MIL projected lineup

  • Brice Turang (2B)
  • Jackson Chourio (CF)
  • William Contreras (C)
  • Christian Yelich (DH)
  • Rhys Hoskins (1B)
  • Isaac Collins (LF)
  • Sal Frelick (RF)
  • Caleb Durbin (3B)
  • Joey Ortiz (3B)
  • Jose Quintana (SP, 4-1 | 2.77 ERA | 27 K)
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Padres vs. Brewers picks and game prediction

The Brewers are slightly favored in the contest, given starter Jose Quintana's record this season and the team's momentum. Game 2 should be a tight affair like the opening matchup, given the pedigree of both teams.

Run Line: MIL +1.5 (-197)

Total Runs: U 8.5 (-114)

Prediction: SD wins, 4-3

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Edited by Daniel Santiago
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