Padres vs Pirates: Game 3 prediction, odds, injuries, and picks

The Pittsburgh Pirates were able to get their first win against the San Diego Padres in five attempts this season with a shutout 5-0 victory on Saturday thanks to a 2-hit 6.1 innings outing by ace Bailey Falter. The road team had dropped the first game to San Diego in a close 3-2 loss.

The Pirates are trying to get back in form, and a win on Sunday would be their 8th win in 12 games. They are last in the NL Central with a 22-37 record. The gap between the Padres and the Los Angeles Dodgers in the NL West standings has grown to 3.0 games. They are 5-5 in their last ten games, getting outscored by 21 runs.

Padres vs. Pirates Game 3: Betting Odds & Weather

Date & Time: Sunday, June 1, 2025 at 5:10 p.m. ET

Money Line: Padres -229

Over/Under: Over 7.5 runs

Weather: Partly Cloudy, 72 degrees F, Wind 10 mph L-R, 39% chance of precipitation

Padres vs. Pirates Game 3: Injuries & Lineups

Injuries

Padres

Jason Heyward: 10 Day IL (Oblique),
Mason McCoy: 10 Day IL (Finger),
Logan Gillaspie: 15 Day IL (Oblique ),
Yu Darvish: 15 Day IL (Elbow),
Michael King: 15 Day IL (Shoulder),
Jhony Brito: 60 Day IL (Forearm),
Bryan Hoeing: 60 Day IL (Shoulder),
Matt Waldron: 60 Day IL (Oblique),
Joe Musgrove: 60 Day IL (Elbow)

Pirates

Colin Holderman: 15 Day IL (Thumb),
Tim Mayza: 60 Day IL (Shoulder),
Justin Lawrence: 60 Day IL (Elbow),
Johan Oviedo: 60 Day IL (Elbow),
Nick Gonzales: 60 Day IL (Ankle),
Dauri Moreta: 60 Day IL (Elbow),
Jared Jones: 60 Day IL (Elbow),
Enmanuel Valdez: 60 Day IL (Shoulder),
Joey Bart: 7 Day IL (Concussion)

Expected Lineups

Padres

RF F. Tatis [R]
1B Luis Arraez [L]
DH M. Machado [R]
CF J. Merrill [L]
SS X. Bogaerts [R]
2B J. Cronenworth [L]
3B J. Iglesias [R]
LF B. Lockridge [R]
C M. Maldonado [R]

Pirates

CF Oneil Cruz [L]
DH A. McCutchen [R]
RF B. Reynolds [S]
LF A. Canario [R]
1B S. Horwitz [L]
C Henry Davis [R]
2B Adam Frazier [L]
3B K. Hayes [R]
SS I. Kiner-Falefa [R]

Padres vs. Pirates Game 3: Prediction and Picks

The starting pitching matchup is expected to be a close-fought contest. Padres' Randy Vasquez (3-4, 3.58 ERA, 1.39 WHIP, 32 SOs) and Pirates' Andrew Heaney (3-4, 3.41 ERA, 1.22 WHIP, 44 SOs) have near identical numbers and both will be making their 12th starts of the season.

The Pirates offense is better off with a .280 average in their last ten games, compared to Padres' .200 team average. Bryan Reynolds has hit 15-for-39 with 12 RBIs during that stretch for Pittsburgh.

For San Diego, Gavin Sheets has been a big find, having hit 11 RBIs, including 5 home runs, in his last ten games. Oneil Cruz and Fernando Tatis Jr. lead their respective teams in home runs hit.

Prediction: Padres 4, Pirates 3

Picks: Padres -229

About the author

Nikhil Parshy is a baseball and ice hockey journalist at Sportskeeda, and after starting out as a cricket reporter, he has been an analyst with SK since November 2022. His interest in the sports were piqued a few years back after watching highlights on YouTube and he has followed the game ever since.

The Chicago Cubs breaking the 108-year curse in 2016 to lift the World Series remains Nikhil's favorite baseball moment. Two-way phenom Shohei Ohtani has been his favorite player ever since he started following the game, while the LA Dodgers are his favorite team.

As a writer, Nikhil maintains a strong attention to detail and rigorously cross-checks information. He seeks to strike a balance in his writing such that the regular reader gains an insight into player profiles, while also keeping in mind that the non-regular reader is not put off by jargon and shallow analysis.

Nikhil is an avid public speaker, and when not writing about baseball, he regularly participates in debates and quizzes.

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Edited by Chaitanya Prakash

Padres vs Pirates: Game 3 prediction, odds, injuries, and picks - June 1, 2025

Padres vs. Pirates Game 3: Betting Odds & Weather

Padres vs. Pirates Game 3: Injuries & Lineups

Injuries

Padres

Pirates

Expected Lineups

Padres

Pirates

Padres vs. Pirates Game 3: Prediction and Picks