Inter Milan, currently at the top of the Serie A standings, kicked off 2022 with a 2-1 win over Lazio on Sunday.
Meanwhile, Juventus consolidated their fifth place in the league standings with a thrilling 4-3 win at Roma, scoring three goals in seven minutes to complete a memorable comeback.
Juventus have won the trophy a record nine times so far and regained the title last year after losing it to Lazio in 2019. Inter's last tasted success in the competition in 2010.
Historically, Serie A winners have done well in the competition, so the hosts will be fancying their chances of overcoming Juventus, who are making their 10th consecutive appearance here.
Inter Milan vs Juventus Head-to-Head
This will be the 257th edition of the Derby d'Italia. Juventus hold the upper hand against their Milan-based rivals and lead 114-78 in wins while the spoils have been shared 64 in this fixture.
They have met just once previously in the Supercoppa Italiana, with Inter recording a 1-0 win in the 2005 edition. They last met in Serie A action at the San Siro in October, with the game ending in a 1-1 draw.
Inter Milan form guide (all competitions): W-W-W-W-L
Juventus form guide (Serie A): W-D-W-W-D
Inter Milan vs Juventus Team News
There are no reported injury concerns for the club, and all players who tested positive for COVID-19 have returned to training. Hakan Calhanoglu will return from a one-game suspension.
Juventus won't be able to count upon the services of Leonardo Bonucci, Federico Chiesa and Danilo for the game while Alex Sandro is a doubt.
Juan Cuadrado and Matthijs de Ligt are suspended, with the Colombian defender picking up his fifth yellow card of the campaign and De Ligt booked twice against Roma.
Injured: Leonardo Bonucci, Federico Chiesa, Danilo
Doubtful: Alex Sandro
Suspended: Juan Cuadrado, Matthijs de Ligt
Inter Milan vs Juventus Predicted XI
Inter Milan Predicted XI (3-5-2): Samir Handanovic; Milan Skriniar, Stefan de Vrij, Alessandro Bastoni; Denzel Dumfries, Nicolo Barella, Marcelo Brozovic, Hakan Calhanoglu, Ivan Perisic; Lautaro Martinez, Edin Dzeko
Juventus Predicted XI (4-4-2): Wojciech Szczesny; Luca Pellegrini, Giorgio Chiellini, Daniele Rugani, Mattia De Sciglio; Weston McKennie, Manuel Locatelli, Rodrigo Bentancur, Federico Bernardeschi; Paulo Dybala, Moise Kean
Inter Milan vs Juventus Prediction
Inter Milan have nine wins in their last 10 games, with their only loss coming to Real Madrid in the Champions League. They last faced a defeat against an Italian opponent in October and are unbeaten at the San Siro since September.
Juventus are also unbeaten in their last eight games across all competitions but will be without key players heading into this game. The encounter between the two sides always makes for an interesting watch and with both of them in great form, it is expected to be a closely contested affair.
We predict the Nerazzurri will overcome the Bianconeri, with Calhanoglu and Dzeko expected to play a major role here.
Prediction: Inter Milan 2-1 Juventus
Q. Will Inter Milan continue their unbeaten run at San Siro with a with a win over Juventus on Wednesday?
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