This Wednesday sees Lyon play host to Monaco in the quarter-finals of the Coupe de France at the Parc Olympique Lyonnais.Monaco represent Lyon’s first Ligue 1 opponents in this season’s Coupe de France, while the visitors have beaten Nice and Metz.So which of these two Ligue 1 powerhouses will make the semi-finals?Lyon vs Monaco Head-to-HeadLyon are currently on one of their best runs of the season, having lost just once in their past eight matches.Most recently, they defeated Nantes 1-2 thanks to a brace from Dutch forward Memphis Depay.In terms of the Coupe de France, Lyon have eliminated three lower-level teams: Ajaccio, Sochaux and Red Star.Monaco, meanwhile, are on a genuinely incredible run right now. Since December 20th they’ve lost just once – a 1-0 defeat to Strasbourg – and have won 14 Ligue 1 games, putting them in 3rd place.Their last match saw them thump Bordeaux 0-3, and in their last four games, they’ve scored 14 goals and conceded none.In the Coupe de France, Monaco have beaten Grenoble, Nice and most recently Metz.The last game between the two sides ended in favor of Lyon, who ran out 4-1 winners despite being reduced to ten men.Lyon form guide: L-D-W-W-WMonaco form guide: W-W-W-W-W📸 #FCNOL (1-2) pic.twitter.com/Rp3b6LrN9u— Olympique Lyonnais 🇬🇧🇺🇸 (@OL_English) April 19, 2021Lyon vs Monaco Team NewsLyonLyon have just two players unavailable with injuries for this game, meaning their squad is almost at full strength.Injured: Tino Kadewere, Djamel BenlamriDoubtful: NoneSuspended: NoneMonacoA COVID-19 outbreak has sidelined four of Monaco’s squad for this game, while influential midfielder Cesc Fabregas is also out with a muscle injury.Injured: Cesc FabregasDoubtful: NoneSuspended: NoneUnavailable: Enzo Miliot, Chrislain Matsima, Eliot Matazo, Krepin Diatta𝐂𝐨𝐮𝐧𝐭'𝐞𝐦: 14 steps to heaven 🤩 #FCGBASM pic.twitter.com/Lk1Zs4Ws0X— AS Monaco EN (@AS_Monaco_EN) April 19, 2021Lyon vs Monaco Predicted XILyon predicted XI (4-2-3-1): Anthony Lopes, Leo Dubois, Marcelo, Jason Denayer, Maxwel Cornet, Maxence Caqueret, Thiago Mendes, Karl Toko Ekambi, Rayan Cherki, Memphis Depay, Islam SlimaniMonaco predicted XI (4-2-3-1): Benjamin Lecomte, Djibril Sidibe, Axel Disasi, Guillermo Maripan, Caio Henrique, Youssouf Fofana, Aurelien Tchouameni, Ruben Aguilar, Aleksandr Golovkin, Sofiane Diop, Wissam Ben YedderLyon vs Monaco PredictionGiven the excellent form of both sides, this is a really tricky match to call.However, Lyon’s home advantage, as well as the talent of players like Memphis, Cherki and Ekambi, means they should have a very slight edge.Prediction: Lyon 1-0 Monaco