Manchester City are back in action in the UEFA Champions League this week as they take on RB Leipzig in a Group A encounter on Wednesday. Pep Guardiola's charges have been impressive this season and will want to win this game.RB Leipzig have been fairly inconsistent this year and have their work cut out for them this week. The German outfit suffered a 4-1 defeat against Bayern Munich over the weekend and cannot afford a similar result on Wednesday.Manchester City, on the other hand, have an excellent squad and have a point to prove in this fixture. The Cityzens edged Leicester City to a narrow victory in their previous game and will need to be at their best in this match.Nights under the lights! 🤩City are back in @ChampionsLeague action on Wednesday night as we take on RB Leipzig - make sure you're there! ⬇️🔷 #ManCity | https://t.co/axa0klD5re— Manchester City (@ManCity) September 13, 2021Manchester City vs RB Leipzig Head-to-HeadManchester City have never faced RB Leipzig in a European fixture and will have to be wary of an upset this week. The Germans can pack a punch on their day and have pulled off impressive results in the UEFA Champions League.RB Leipzig will likely set up on the counter against Manchester City and will need to adapt to Pep Guardiola's approach. The Premier League giants have been prone to counter-attacking setups and will need to put up a robust front on Wednesday.Manchester City form guide: W-W-W-L-LRB Leipzig form guide: L-L-W-L-WManchester City vs RB Leipzig Team NewsManchester City hold the upper handManchester CityZack Steffen has tested positive for the coronavirus and will not be included in the squad for this game. Benjamin Mendy is currently in police custody and will not be able to feature in this match.Injured: NoneDoubtful: NoneUnavailable: Zack Steffen, Benjamin MendyRB Leipzig need to win this gameRB LeipzigMarcel Halstenberg and Marcelo Saracchi are carrying injuries at the moment and have been ruled out of this match. RB Leipzig have plenty of talent at their disposal and will need to field their best team against Manchester City.Injured: Marcel Halstenberg, Marcelo SaracchiDoubtful: NoneSuspended: NoneManchester City vs RB Leipzig Predicted XIManchester City Predicted XI (4-3-3): Ederson Moraes; Oleksandr Zinchenko, Ruben Dias, John Stones, Kyle Walker; Rodri, Ilkay Gundogan, Kevin De Bruyne; Riyad Mahrez, Ferran Torres, Raheem Sterling#UCL week means a new ball in training ⚽🔴⚪ #WeAreLeipzig pic.twitter.com/s1feCcQOcG— RB Leipzig English (@RBLeipzig_EN) September 13, 2021RB Leipzig Predicted XI (4-2-3-1): Peter Gulacsi; Angelino, Mohamed Simakan, Willi Orban, Lukas Klostermann; Amadou Haidara, Tyler Adams; Emil Forsberg, Christopher Nkunku, Dominik Szoboszlai; Andre SilvaManchester City vs RB Leipzig PredictionManchester City have excellent players in their ranks and will be intent on proving their mettle in Europe this season. Pep Guardiola's charges lost out to Chelsea earlier this year and will need to make amends in the coming months.RB Leipzig are perfectly capable of pulling off an upset but will need to play out of their skins this week. Manchester City are the better team at the moment and should be able to win this game.Prediction: Manchester City 3-1 RB Leipzig