Manchester City will take on Southampton in the Premier League on Wednesday, hoping to bounce back from their derby defeat.Pep Guardiola’s side were beaten 2-0 at the Etihad by Manchester United on Sunday. The defeat put an end to their 21-game winning streak across all competitions.Although Manchester City still have an 11-point lead at the top of the Premier League table, they will look to go on another winning run.Recover and refocus 💪🔷 #ManCity | https://t.co/axa0klUGiM pic.twitter.com/7tMk5BEtkF— Manchester City (@ManCity) March 8, 2021Southampton, on the other hand, picked up a morale-boosting win against Sheffield United to end their four-game winless run in the league.Manchester City vs Southampton Head-to-headManchester City have dominated this fixture, having won 19 times against the Saints. Southampton have won seven, and drawn seven of their games.In the last 10 games against Manchester City, Southampton have won just once. Ralph Hasenhuttl’s side beat Manchester City at home last season courtesy of a Che Adams goal.Manchester City form guide: W-W-W-W-LSouthampton form guide: L-D-L-L-WManchester City vs Southampton Team NewsManchester CityManchester City will still be without defender Nathan Ake. Phil Foden is pushing for a start and he could feature in place of Riyad Mahrez, who started in the derby. Joao Cancelo could also drop to the bench for Kyle Walker.Doubtful: Nathan AkeSuspended: NoneSouthamptonDanny Ings will miss out after picking up a muscle injury, and his absence will be a big blow. Michael Obafemi and Theo Walcott are the other attackers who will be unavailable.The manager has provided an update on @IngsDanny after he was forced off through injury at the weekend:— Southampton FC (@SouthamptonFC) March 8, 2021Ibrahima Diallo and James Ward-Prowse are expected to start in midfield with Oriol Romeu out injured.Injured: Danny Ings, Michael Obafemi, Theo Walcott, Oriol Romeu, William SmallboneSuspended: NoneManchester City vs Southampton Predicted LineupsManchester City Probable XI (4-3-3): Ederson; Kyle Walker, Ruben Dias, John Stones, Oleksandr Zinchenko; Rodri, Ilkay Gundogan, Kevin De Bruyne; Raheem Sterling, Phil Foden, Gabriel JesusSouthampton Probable XI (4-4-2): Fraser Forster; Ryan Bertrand, Jannik Vestergaard, Jan Bednarek, Kyle Walker-Peters; Takumi Minamino, James Ward-Prowse, Ibrahima Diallo, Stuart Armstrong; Che Adams, Nathan TellaManchester City vs Southampton PredictionManchester City will want to immediately recapture their winning form as they have a crucial few weeks coming up.The club can still win a quadruple this season. However, they can’t afford to take their foot off the pedal despite an 11-point lead at the top of the Premier League table.We believe Guardiola’s side will have too much quality for Southampton.Score prediction: Manchester City 2-1 Southampton